Comparing the effects of cinnamaldehyde and eugenol in collagen induced arthritis

Objectives: The present study was done to compare the effects of cinnamaldehdye and eugenol on severity of arthritis in CIA rat model in terms of joint swelling, cartilage damage and bone erosion. Moreover, markers of oxidative stress and inflammation were also monitored in treated and untreated rat...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.36 (S1), p.S45
Main Authors: Mateen, Somaiya, Shahzad, Summayya, Moin, Shagufta
Format: Article
Language:English
Subjects:
Aldehydes
Analysis
Antiarthritic agents
Arthritis
Collagen
Cytokines
Phenols
Rheumatoid factor
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Summary:Objectives: The present study was done to compare the effects of cinnamaldehdye and eugenol on severity of arthritis in CIA rat model in terms of joint swelling, cartilage damage and bone erosion. Moreover, markers of oxidative stress and inflammation were also monitored in treated and untreated rats. Methods: Female wistar rats were immunized with type II collagen and treated with cinnamaldehyde and eugenol in order to observe its anti-arthritic potential. The effect of treatment was monitored by clinical scoring, cytokines level, biochemical markers, radiological examination and histological evaluations in the joints. Results: Cinnamaldehyde and eugenol were found to decrease the severity of arthritis in rats as evidenced by decreased paw swelling, arthritis index and organ indices. The changes were found to be more prominent in eugenol treated group. Histopathological and radiological examination revealed decreased cartilage damage and bone erosion in the treated group. Similarly oxidative stress markers (reactive oxygen and nitrogen species, markers of protein, lipid and DNA damage), enzymatic and non-enzymatic antioxidants) and inflammatory cytokines (TNF-a, IL-6, IL-10) were also ameliorated in treated groups, with the amelioration being more significant in eugenol treated arthritic rats. Scanning electron microscopy further revealed reduction in oxidative stress in the treatment group. Conclusion: Eugenol was more effective than cinnamladehyde in managing cartilage damage, bone erosion, oxidative stress and inflammation in rats. Therefore, these compounds may be used as an adjunct to the currently available anti-rheumatic drugs for the management of RA. Keywords: Rheumatoid arthritis, cinnamaldehyde, eugenol, oxidative stress, inflammation
ISSN:0970-1915