Hemodynamic Evaluation of Patients with Moyamoya: Comparison of Resting-State-fMRI to Breath-Hold-fMRI

Background & Purpose: Patients with Moyamoya Disease (MMD) require the estimation of remaining cerebrovascular reactivity (CVR), for example by breath-hold(bh)-triggered-fMRI [1]. Recent findings suggest the use of resting-state (rs)-fMRI [2]. The aim of this study was to compare rs-fMRI to bh-f...

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Bibliographic Details
Published in:Clinical neuroradiology (Munich) 2020-09, Vol.30 (S1), p.S17
Main Authors: Zerweck, L, Hauser, T.K, Roder, C, Ernemann, U, Klose, U
Format: Article
Language:English
Subjects:
Comparative analysis
Magnetic resonance imaging
Patient compliance
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Summary:Background & Purpose: Patients with Moyamoya Disease (MMD) require the estimation of remaining cerebrovascular reactivity (CVR), for example by breath-hold(bh)-triggered-fMRI [1]. Recent findings suggest the use of resting-state (rs)-fMRI [2]. The aim of this study was to compare rs-fMRI to bh-fMRI. Methods: rs- and bh-fMRI data sets of 7 MMD patients were realigned, normalized, segmented into 6 standardized ROIs [3] and spatially smoothed. The bh-images were additionally slice-time corrected. The rs-data was temporally band-pass filtered (0.02-0.04 Hz). bhCVR-maps (Fig. 1b) were calculated by voxel-wise integrating the signal time-course and rs-CVR-maps (Fig. 1a) were calculated by linear regression analysis in which the cerebellar time-course was the regressor. We compared the mean CVR of the 6 ROIs (Fig. 2a) of all patients. Results: The CVR-maps of both modalities showed high correlation (correlation coefficient = 0.80, p < 0.001, Fig. 2b). Conclusion: rs-fMRI seems to be a promising method for hemodynamic evaluation. It requires minimum patient compliance and no complex equipment.
ISSN:1869-1439