Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction

Orcinol glucoside (OG), mainly found in the rhizome of the traditional Chinese herb Curculigo orchioides Gaertn, is noted for its antidepressant effects. In this study, an efficient screening pipeline was established for identifying the highly active orcinol synthase (ORS) and UDP-dependent glycosyl...

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Bibliographic Details
Published in:	PLoS biology 2023-06, Vol.21 (6), p.e3002131
Main Authors:	Chen, Bihuan, Liu, Xiaonan, Wang, Yina, Bai, Jie, Liu, Xiangyu, Xiang, Guisheng, Liu, Wei, Zhu, Xiaoxi, Cheng, Jian, Lu, Lina, Zhang, Guanghui, Zhang, Ge, Dai, Zongjie, Zi, Shuhui, Yang, Shengchao, Jiang, Huifeng
Format:	Article
Language:	English
Subjects:	Antidepressants Aquatic plants Ascomycota Biology and Life Sciences Biosynthesis Candidates Chemical properties Computer and Information Sciences Engineering and Technology Enzymatic activity Enzyme activity Enzymes Fermentation Fungi Gene expression Genetically modified organisms Glucosides Glucosides - metabolism Glycosyltransferase Health aspects Herbal medicine Independent sample Liliopsida Materia medica, Vegetable Medicine and Health Sciences Metabolic engineering Metabolic Engineering - methods Metabolism Natural products Optimization Pharmaceutical research Physical Sciences Physiological aspects Plant extracts Production processes Research and analysis methods Rhizomes Screening Standard deviation Transcriptomes Yarrowia - genetics Yarrowia lipolytica
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