Frequency of asymptomatic hyperuricemia in advanced-stage symptomatic knee osteoarthritis and its relationship with inflammatory parameters /Ileri evre semptomatik diz osteoartritinde asemptomatik hiperurisemi sikligi ve inflamatuar parametreler ile iliskisi

Purpose: Hyperuricemia (HU) is thought to be a risk factor in the development and progression of knee osteoarthritis (OA). We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retr...

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Bibliographic Details
Published in:Pamukkale Medical Journal 2024-07, Vol.17 (3), p.412
Main Authors: Cobanoglu, Reyhan Kose, Akbas, Bilal Bedirhan, Yildiz, Vahit, Ozgezmez, Ferit Tufan
Format: Article
Language:English
Subjects:
Blood
Body mass index
C-reactive protein
Development and progression
Hyperuricemia
Inflammation
Medical examination
Medical research
Medicine, Experimental
Osteoarthritis
Risk factors
Uric acid
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Summary:Purpose: Hyperuricemia (HU) is thought to be a risk factor in the development and progression of knee osteoarthritis (OA). We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retrospective study including patients with symptomatic stage 3/4 knee OA classified based on Kellgren-Lawrence (K-L) system. Demographic data and serum uric acid (UA), hemogram parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), body mass index (BMI) were recorded. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index (SII)=[(neutrophil count * platelet count)/lymphocyte count] were calculated. Patients with/without hyperuricemia were defined as Group 1 and Group 2, respectively. Demographic and laboratory data were compared between the groups. Results: Hyperuricemia was present in 51 of 240 patients (21%). There was no significant difference between the groups based on age (Group 1: 70.54[+ or -]7.02, Group 2: 68.63[+ or -]6.29, p=0.07) and BMI (Group 1: 34 kg/[m.sup.2] (27.7-41), Group 2: 32 kg/[m.sup.2] (25-51.5), p=0.107). NLR, PLR, and SII were similar between two groups (p=0.404, p=0.604, p=0.537). While there was no difference in ESR values between the two groups (p=0.051), CRP levels were found to be significantly higher in Group 1 (p=0.007). A positive correlation was detected between serum UA level and CRP (rho=0.243**, p
ISSN:1309-9833
DOI:10.31362/patd.1407943