Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women

Background/Objectives: Conversion of saturated fatty acids to monounsaturated fatty acids by the enzyme stearoyl-Co-A-desaturase (SCD-1) is emerging as a major factor in promoting carcinogenesis including breast cancer. The aim of our study was to explore the regulation of SCD-1 by Raloxifene and om...

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Published in:	European journal of clinical nutrition 2017-06, Vol.71 (6), p.762-765
Main Authors:	Manni, A, Richie, J P, Schetter, S E, Calcagnotto, A, Trushin, N, Aliaga, C, El-Bayoumy, K
Format:	Article
Language:	English
Subjects:	692/308 692/53 Adult Aged Antiestrogens Biomarkers Biomarkers - blood Body Mass Index Body size Breast cancer Breast Density - drug effects Breast Neoplasms - blood Breast Neoplasms - prevention & control Carcinogenesis Carcinogens Clinical Nutrition Clinical trials Density Desaturase Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - blood Dose-Response Relationship, Drug Drug Combinations Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - blood Enzymes Epidemiology Estrogen Receptor Modulators - administration & dosage Estrogen Receptor Modulators - blood Estrogen receptors Fatty acids Fatty Acids - blood Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - blood Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - blood Female Follow-Up Studies Health aspects Health risks Humans Internal Medicine Mammography Medical schools Medicine Medicine & Public Health Metabolic Diseases Middle Aged Obesity Obesity - blood Obesity - physiopathology Oleic acid Oleic Acid - administration & dosage Oleic Acid - blood Omega 3 fatty acids original-article Overweight persons Palmitic acid Palmitic Acid - administration & dosage Palmitic Acid - blood Palmitoleic acid Plasma Post-menopause Postmenopausal women Postmenopause Prevention Public Health Raloxifene Raloxifene Hydrochloride - administration & dosage Raloxifene Hydrochloride - blood Ratios Reduction Risk Risk Factors Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - blood University colleges Womens health
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