A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 – 4 . The detection of pathogen-derived nucleic acids is a central strategy by which the host senses infection and initiates protective immune responses 5 , 6 . Cyclic GMP-AMP synthase (cGAS) is a double-strand...

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Published in:	Nature (London) 2019-05, Vol.569 (7758), p.718-722
Main Authors:	Zhao, Baoyu, Du, Fenglei, Xu, Pengbiao, Shu, Chang, Sankaran, Banumathi, Bell, Samantha L., Liu, Mengmeng, Lei, Yuanjiu, Gao, Xinsheng, Fu, Xiaofeng, Zhu, Fanxiu, Liu, Yang, Laganowsky, Arthur, Zheng, Xueyun, Ji, Jun-Yuan, West, A. Phillip, Watson, Robert O., Li, Pingwei
Format:	Article
Language:	English
Subjects:	14/19 631/250/262 631/535/1258 631/535/1266 82/1 82/103 82/16 82/29 82/58 82/80 82/83 Amino Acid Motifs Analysis Antagonists Autoimmune diseases BASIC BIOLOGICAL SCIENCES Chemical synthesis Conserved Sequence Crystallography, X-Ray Cyclic GMP EF hand proteins Enzyme Activation HEK293 Cells Humanities and Social Sciences Humans Hydrogen bonds Immune response Influence Interferon Interferon regulatory factor 3 Interferon-beta - metabolism Letter Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Models, Molecular multidisciplinary Mutation Nucleic acids Nucleotides, Cyclic - metabolism Oligomerization Peptides Phosphorylation Protein Binding Protein kinases Protein Serine-Threonine Kinases - metabolism Science Science (multidisciplinary) Signal Transduction β-Interferon
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