Meis1 regulates postnatal cardiomyocyte cell cycle arrest

The neonatal heart has a high regenerative capacity that is lost in adult life; the transcription factor Meis1 has been identified as a relevant proliferative switch for this transition, providing a potential therapeutic target for adult heart regeneration. Heart cells that keep on growing Adult mam...

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Bibliographic Details
Published in:Nature (London) 2013-05, Vol.497 (7448), p.249-253
Main Authors: Mahmoud, Ahmed I., Kocabas, Fatih, Muralidhar, Shalini A., Kimura, Wataru, Koura, Ahmed S., Thet, Suwannee, Porrello, Enzo R., Sadek, Hesham A.
Format: Article
Language:English
Subjects:
631/443/592/2725
631/80
Alleles
Animals
Animals, Newborn
Apoptosis
Cardiomyocytes
Cell cycle
Cell Cycle Checkpoints
Cell Proliferation
Cellular control mechanisms
Cyclin-Dependent Kinase Inhibitor p15 - metabolism
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Female
Gene expression
Heart
Heart - anatomy & histology
Heart - physiology
Heart attacks
Heart cells
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humanities and Social Sciences
Kinases
letter
Male
Mice
multidisciplinary
Myeloid Ecotropic Viral Integration Site 1 Protein
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Neoplasm Proteins - deficiency
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Proteins
Regeneration
Science
Transcriptional Activation
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