CTG Trinucleotide Repeat “Big Jumps”: Large Expansions, Small Mice

Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not...

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Bibliographic Details
Published in:PLoS genetics 2007-04, Vol.3 (4), p.e52
Main Authors: Gomes-Pereira, Mário, Foiry, Laurent, Nicole, Annie, Huguet, Aline, Junien, Claudine, Munnich, Arnold, Gourdon, Geneviève
Format: Article
Language:English
Subjects:
Age
Alleles
Animals
Base Sequence
Body Size - genetics
Causes of
Deoxyribonucleic acid
Disease
DNA
Genetic disorders
Genetics
Genetics and Genomics
Genomic Instability - genetics
Glutamate
Homozygote
Humans
Mental retardation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Biology
Mus (Mouse)
Mutation
Myotonic dystrophy
Neurological Disorders
Neuromuscular diseases
Pathogenesis
RNA Splicing - genetics
Rodents
Trinucleotide Repeat Expansion - genetics
Trinucleotide repeats
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