Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed pathological tau in Alzheimer's disease, and in frontotemporal lobar degeneration associated with tauopathy to include cases with Pick bodies, cort...

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Bibliographic Details
Published in:	Acta neuropathologica 2016-02, Vol.131 (2), p.267-280
Main Authors:	新井哲明, Taniguchi-Watanabe Sayuri, Arai Tetsuaki, Kametani Fuyuki, Nonaka Takashi, Masuda-Suzukake Masami, Tarutani Airi, Murayama Shigeo, Saito Yuko, Arima Kunimasa, Yoshida Mari, Akiyama Haruhiko, Robinson Andrew, Mann David M. A., Iwatsubo Takeshi, Hasegawa Masato
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Alzheimer's disease Amino Acid Sequence Analysis Brain - ultrastructure Brain Chemistry Disease Female Humans Immunoblotting - methods Male Mass spectrometry Mass Spectrometry - methods Medicine Medicine & Public Health Microscopy, Immunoelectron - methods Middle Aged Mutation Neuropathology Neurosciences Original Paper Pathology Protein Conformation Proteins Sarcosine - analogs & derivatives Sarcosine - metabolism Sequence Analysis, Protein - methods tau Proteins - chemistry tau Proteins - metabolism Tauopathies - classification Tauopathies - metabolism Tauopathies - pathology Trypsin Trypsin - metabolism
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