Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study

Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota determines the presence of certain cytokines locally. We assessed the association between cervical microbiota diversity and the h...

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Bibliographic Details
Published in:PloS one 2016-04, Vol.11 (4), p.e0153274
Main Authors: Audirac-Chalifour, Astride, Torres-Poveda, Kirvis, Bahena-Román, Margarita, Téllez-Sosa, Juan, Martínez-Barnetche, Jesús, Cortina-Ceballos, Bernardo, López-Estrada, Guillermina, Delgado-Romero, Karina, Burguete-García, Ana I., Cantú, David, García-Carrancá, Alejandro, Madrid-Marina, Vicente
Format: Article
Language:English
Subjects:
Adult
Analysis
Bacteria
Biology and Life Sciences
Cancer
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - microbiology
Carcinoma, Squamous Cell - pathology
Cervical cancer
Cervix
Cross-Sectional Studies
Cytokines
Cytokines - genetics
Cytology
Diagnosis
Ecology and Environmental Sciences
Female
Fusobacterium
Gene expression
Health risks
Human papillomavirus
Humans
Immunosuppression
Interferon
Interferon-gamma - genetics
Interleukin 10
Interleukin 4
Interleukin 6
Interleukin-10 - genetics
Interleukin-4 - genetics
Interleukin-6 - genetics
Lesions
Medicine and Health Sciences
Microbiomes
Microbiota
Middle Aged
Neoplasm Staging
Next-generation sequencing
Papillomavirus infections
Research and Analysis Methods
Risk factors
RNA, Messenger - genetics
RNA, Neoplasm - genetics
rRNA 16S
Squamous Intraepithelial Lesions of the Cervix - immunology
Squamous Intraepithelial Lesions of the Cervix - microbiology
Squamous Intraepithelial Lesions of the Cervix - pathology
Transcriptome
Transforming Growth Factor beta1 - genetics
Transforming growth factor-b1
Tumor Necrosis Factor-alpha - genetics
Tumor necrosis factor-α
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - microbiology
Uterine Cervical Neoplasms - pathology
Vagina
γ-Interferon
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