Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Background Baicalin, which is isolated from Radix Scutellariae , possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 (TLR4), which participates in pathological change...

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Published in:	Journal of neuroinflammation 2019-05, Vol.16 (1), p.95-21, Article 95
Main Authors:	Guo, Li-Ting, Wang, Si-Qi, Su, Jing, Xu, Li-Xing, Ji, Zhou-Ye, Zhang, Ru-Yi, Zhao, Qin-Wen, Ma, Zhan-Qiang, Deng, Xue-Yang, Ma, Shi-Ping
Format:	Article
Language:	English
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Animals Anti-Inflammatory Agents - pharmacology Baicalin Behavior Biomedical and Life Sciences Biomedicine Brain research Central nervous system Central nervous system diseases Complications and side effects Cytokines Depression Depression - etiology Depression - immunology Depression, Mental Drug therapy Enzyme-linked immunosorbent assay Flavonoids - pharmacology Forkhead Box Protein O1 - metabolism Forkhead protein FoxO1 FOXO1 protein Gene expression IL-1β Immunology Inflammation Inflammation - metabolism Interleukin 1 Interleukin 6 Kinases Lipopolysaccharides Male Mental depression Mice Mice, Inbred ICR Microglia Microglial cells Molecular modelling Nervous system diseases Neurobiology Neuroinflammation Neurology Neuroprotective agents Neurosciences Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Proto-Oncogene Proteins c-akt - metabolism Psychological Distress - complications Psychological Distress - immunology Risk factors Signal Transduction - drug effects siRNA Testing TLR4 TLR4 protein Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - drug effects Toll-like receptors Transcription factors Tumor necrosis factor-TNF Tumor necrosis factor-α
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