Effects of the obese gene product on body weight regulation in ob/ob mice

C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of gl...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5223), p.540-543
Main Authors:	Pelleymounter, M.A. (Amgen, Inc., Thousand Oaks, CA.), Cullen, M.J, Baker, M.B, Hecht, R, Winters, D, Boone, T, Collins, F
Format:	Article
Language:	English
Subjects:	Adipose Tissue Adipose Tissue - drug effects ADN RECOMBINADO ADN RECOMBINE analysis Analysis of Variance Animals Biological and medical sciences blood Blood Glucose Blood Glucose - analysis blood serum Body Composition Body Composition - drug effects Body fat Body temperature Body Temperature - drug effects Body weight Classical genetics, quantitative genetics, hybrids Climate Dosage Dose-Response Relationship, Drug Drinking Drinking - drug effects drug effects Eating Eating - drug effects Energy Metabolism Energy Metabolism - drug effects Female Food intake Fundamental and applied biological sciences. Psychology GENE Gene therapy GENES Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution GLUCOSA GLUCOSE INGESTION DE ALIMENTOS Insulin Insulin - blood INSULINA INSULINE Leptin Lipid metabolism Mice Mice, Inbred C57BL Mice, Obese Motor Activity Motor Activity - drug effects Mutation Obesity Obesity - genetics Obesity - physiopathology Obesity gene Oxygen Consumption Oxygen Consumption - drug effects PESO pharmacology physiopathology POIDS PRISE ALIMENTAIRE (HOMME) Protein metabolism PROTEINAS PROTEINE Proteins Proteins - genetics Proteins - pharmacology RATON recombinant DNA Recombinant Proteins Recombinant Proteins - pharmacology Rodents Scientific Concepts SERUM SANGUIN SOBREPESO SOURIS Statistical Analysis SUERO SANGUINEO SURPOIDS TEJIDO ADIPOSO TEMPERATURA DEL CUERPO TEMPERATURE CORPORELLE TISSU ADIPEUX Vertebrata Water Weight control Weight Loss Weight Loss - drug effects
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