An evolutionary scenario for one of the largest yeast gene families

The DUP gene family of Saccharomyces cerevisiae comprises 23 members that can be divided into two subfamilies – DUP240 and DUP380. The location of the DUP loci suggests that at least three mechanisms were responsible for their genomic dispersion: nonreciprocal translocation at chromosomal ends, tand...

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Bibliographic Details
Published in:Trends in genetics 2006, Vol.22 (1), p.10-15
Main Authors: Despons, Laurence, Wirth, Bénédicte, Louis, Véronique Leh, Potier, Serge, Souciet, Jean-Luc
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
chromosome translocation
DUP gene family
evolution
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
fungal proteins
Gene Duplication
Genes, Fungal
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Life Sciences
Molecular and cellular biology
Molecular Sequence Data
Multigene Family
nonreciprocal translocation
Phylogeny
Research Support, Non-U.S. Gov't
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins
Saccharomyces cerevisiae Proteins - genetics
Sequence Homology, Amino Acid
Translocation, Genetic
transposons
yeasts
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Summary:The DUP gene family of Saccharomyces cerevisiae comprises 23 members that can be divided into two subfamilies – DUP240 and DUP380. The location of the DUP loci suggests that at least three mechanisms were responsible for their genomic dispersion: nonreciprocal translocation at chromosomal ends, tandem duplication and Ty-associated duplication. The data we present here suggest that these nonessential genes encode proteins that facilitate membrane trafficking processes. Dup240 proteins have three conserved domains (C1, C2 and C3) and two predicted transmembrane segments (H1 and H2). A direct repetition of the C1–H1–H2–C2 module is observed in Dup380p sequences. In this article, we propose an evolutionary model to account for the emergence of the two gene subfamilies.
ISSN:0168-9525
DOI:10.1016/j.tig.2005.10.001