Highly Enantioselective Synthesis of 3-Hydroxy-2-methylpropanoic Acid Esters through Ruthenium-SYNPHOS®-Catalyzed Hydrogenation: Useful Building Blocks for the Synthetic Community

Both enantiomers of 3‐hydroxy‐2‐methylpropanoic acid tert‐butyl ester were prepared with high enantioselectivity (up to 94 %) through a ruthenium‐SYNPHOS®‐promoted asymmetric hydrogenation reaction using an atom‐economic transformation from simple and inexpensive precursors.

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2007-07, Vol.349 (10), p.1592-1596
Main Authors: Jeulin, Séverine, Ayad, Tahar, Ratovelomanana-Vidal, Virginie, Genêt, Jean-Pierre
Format: Article
Language:English
Subjects:
asymmetric catalysis
Chemical Sciences
hydrogenation
Organic chemistry
Roche ester
ruthenium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Both enantiomers of 3‐hydroxy‐2‐methylpropanoic acid tert‐butyl ester were prepared with high enantioselectivity (up to 94 %) through a ruthenium‐SYNPHOS®‐promoted asymmetric hydrogenation reaction using an atom‐economic transformation from simple and inexpensive precursors.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200700025