Synthesis and Reactivity of 2,3-Dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione

Abstract Based on an orthogonal protective group strategy dealing with N-protected hydrazine, we established for the first time a highly efficient synthetic pathway leading to 2,3-benzodiazepine-1,4-dione. Moreover, the versatile reactivities exhibited by this 2,3-benzodiazepine-1,4-dione were evalu...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2007-12, Vol.2007 (24), p.3791-3796
Main Authors: Bihel, Frédéric J.-J., Hellal, Malik, Bourguignon, Jean-Jacques
Format: Article
Language:English
Subjects:
Chemical Sciences
Medicinal Chemistry
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Summary:Abstract Based on an orthogonal protective group strategy dealing with N-protected hydrazine, we established for the first time a highly efficient synthetic pathway leading to 2,3-benzodiazepine-1,4-dione. Moreover, the versatile reactivities exhibited by this 2,3-benzodiazepine-1,4-dione were evaluated towards both benzylation and amination reactions.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-990893