An environmentally friendly route for the synthesis of benzofurane derivatives using selective ring acylation of resorcinol

The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corr...

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Bibliographic Details
Published in:Catalysis letters 2007-10, Vol.118 (3-4), p.219-223
Main Authors: BEKASSY, Sandor, AGAI, Béla, FARKAS, Janos, GABOR, Eszter, FERENCZI, Maria, FIGUERAS, Francois
Format: Article
Language:English
Subjects:
Acylation
Catalysis
Chemical Sciences
Chemistry
Derivatives
Environment and Society
Environmental Sciences
Exact sciences and technology
General and physical chemistry
Reagents
Synthesis
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corrosive and dangerous reagents/materials, the procedure proposed here achieves 60% preparative yield for the selective direct ring acylation of resorcinol with isobutyryl chloride, using a solvent-free reaction catalysed by solid acids.
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-007-9173-y