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Micro-robotics & MEMS based fabrication techniques for scaffold based tissue engineering

Scaffold based tissue engineering strategies use cells, biomolecules and a scaffold to promote the repair and regeneration of tissues. Although scaffold-based tissue engineering approaches are being actively developed, most are still experimental, and it is not yet clear what defines an ideal scaffo...

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Published in:Macromolecular bioscience 2005-07, Vol.5 (6), p.477-489
Main Authors: Zhang, Han, Hutmacher, Dietmar, Chollet, Franck, Poo, A.N., Burdet, Etienne
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Language:English
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container_end_page 489
container_issue 6
container_start_page 477
container_title Macromolecular bioscience
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creator Zhang, Han
Hutmacher, Dietmar
Chollet, Franck
Poo, A.N.
Burdet, Etienne
description Scaffold based tissue engineering strategies use cells, biomolecules and a scaffold to promote the repair and regeneration of tissues. Although scaffold-based tissue engineering approaches are being actively developed, most are still experimental, and it is not yet clear what defines an ideal scaffold/cell construct. Solid free form fabrication (SFF) techniques can precisely control matrix architecture (size, shape, interconnectivity, branching, geometry and orientation). The SFF methods enable the fabrication of scaffolds with various designs and material compositions, thus providing a control of mechanical properties, biological effects and degradation kinetics. This paper reviews the application of micro-robotics and MEMS-based fabrication techniques for scaffold design and fabrication. It also presents a novel robotic technique to fabricate scaffold/cell constructs for tissue engineering by the assembly of microscopic building blocks.
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subjects Biotechnology
Computer Science
Engineering Sciences
Life Sciences
Micro and nanotechnologies
Microelectronics
Other
title Micro-robotics & MEMS based fabrication techniques for scaffold based tissue engineering
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