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Invertebrate Data Predict an Early Emergence of Vertebrate Fibrillar Collagen Clades and an Anti-incest Model
Fibrillar collagens are involved in the formation of striated fibrils and are present from the first multicellular animals, sponges, to humans. Recently, a new evolutionary model for fibrillar collagens has been suggested (Boot-Handford, R. P., Tuckwell, D. S., Plumb, D. A., Farrington Rock, C., and...
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Published in: | The Journal of biological chemistry 2004-11, Vol.279 (46), p.47711-47719 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Fibrillar collagens are involved in the formation of striated fibrils and are present from the first multicellular animals,
sponges, to humans. Recently, a new evolutionary model for fibrillar collagens has been suggested (Boot-Handford, R. P., Tuckwell,
D. S., Plumb, D. A., Farrington Rock, C., and Poulsom, R. (2003) J. Biol. Chem . 278, 31067â31077). In this model, a rare genomic event leads to the formation of the founder vertebrate fibrillar collagen
gene prior to the early vertebrate genome duplications and the radiation of the vertebrate fibrillar collagen clades (A, B,
and C). Here, we present the modular structure of the fibrillar collagen chains present in different invertebrates from the
protostome Anopheles gambiae to the chordate Ciona intestinalis . From their modular structure and the use of a triple helix instead of C-propeptide sequences in phylogenetic analyses, we
were able to show that the divergence of A and B clades arose early during evolution because α chains related to these clades
are present in protostomes. Moreover, the event leading to the divergence of B and C clades from a founder gene arose before
the appearance of vertebrates; altogether these data contradict the Boot-Handford model. Moreover, they indicate that all
the key steps required for the formation of fibrils of variable structure and functionality arose step by step during invertebrate
evolution. |
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ISSN: | 0021-9258 1083-351X |
DOI: | 10.1074/jbc.M408950200 |