A convenient synthesis of novel spiroisoindolone g-halobutyrolactones via halocyclization of g-ethylenic acids

γ-Ethylenic carboxylic acids are cyclized to spiroisoindolone γ-halomethylbutyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding haloaspirobutyrolactones were isolated in high yields (57-95%).

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Published in:Heterocycles 2009, Vol.78 (11), p.2787-2798
Main Authors: Rammah, M. M., Othman, M., Ciamala, K., Knorr, M., Strohmann, C.
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container_issue 11
container_start_page 2787
container_title Heterocycles
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creator Rammah, M. M.
Othman, M.
Ciamala, K.
Knorr, M.
Strohmann, C.
description γ-Ethylenic carboxylic acids are cyclized to spiroisoindolone γ-halomethylbutyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding haloaspirobutyrolactones were isolated in high yields (57-95%).
doi_str_mv 10.3987/COM-09-11787
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title A convenient synthesis of novel spiroisoindolone g-halobutyrolactones via halocyclization of g-ethylenic acids
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