Photoredox-Initiated α-Alkylation of Imines through a Three-Component Radical/Cationic Reaction

Radical‐polar crossover reaction: The photoredox‐mediated alkylation of enamides with diethyl bromomalonate in the presence of alcohols has been developed. This multicomponent domino process affords β‐alkylated α‐carbamido ethers as stables imine surrogates in good to excellent yields under mild con...

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Bibliographic Details
Published in:Chemistry : a European journal 2012-01, Vol.18 (2), p.423-427
Main Authors: Courant, Thibaut, Masson, Géraldine
Format: Article
Language:English
Subjects:
alkylation
Chemical Sciences
domino reactions
enamides
Organic chemistry
photoredox catalysis
radicals
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Summary:Radical‐polar crossover reaction: The photoredox‐mediated alkylation of enamides with diethyl bromomalonate in the presence of alcohols has been developed. This multicomponent domino process affords β‐alkylated α‐carbamido ethers as stables imine surrogates in good to excellent yields under mild conditions (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201103062