Exported proteins in probiotic bacteria: adhesion to intestinal surfaces, host immunomodulation and molecular cross-talking with the host

The group of exported proteins of a bacterium are those proteins that are sorted from the cytoplasm to the bacterial surface or to the surroundings of the microorganism. In probiotic bacteria, these proteins are of special relevance because they might determine important traits such as adhesion to i...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2008-10, Vol.54 (1), p.1-17
Main Authors: Sánchez, Borja, Bressollier, Philippe, Urdaci, María C
Format: Article
Language:English
Subjects:
Adhesion
Bacteria
Bacteria - immunology
Bacteria - metabolism
Bacterial Adhesion
Bacterial Proteins - immunology
Bacterial Proteins - metabolism
Bacterial Proteins - secretion
Bacteriology
Bifidobacterium - immunology
Bifidobacterium - metabolism
Biological and medical sciences
Chemical Sciences
Crosstalk
Cytoplasm
Exports
Fundamental and applied biological sciences. Psychology
Gastrointestinal system
Gastrointestinal tract
host interaction
Humans
Immunomodulation
Intestine
Intestines - cytology
Intestines - immunology
Intestines - metabolism
Intestines - microbiology
Lactobacillus - immunology
Lactobacillus - metabolism
Microbiology
Miscellaneous
Organic chemistry
outer membrane proteins
Probiotics
Proteins
secreted proteins
Signal Transduction
surface proteins
TCF Transcription Factors
Transcription Factor 7-Like 2 Protein
Yogurt
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Summary:The group of exported proteins of a bacterium are those proteins that are sorted from the cytoplasm to the bacterial surface or to the surroundings of the microorganism. In probiotic bacteria, these proteins are of special relevance because they might determine important traits such as adhesion to intestinal surfaces and molecular cross-talking with the host. Current knowledge about the presence and biological relevance of exported proteins produced by the main genera of probiotic bacteria in the gastrointestinal environment is reviewed in this minireview. As will be seen, some of these proteins are involved in host adhesion or are able to modify certain signalization pathways within host cells, whereas others are important for the physiology of probiotic bacteria in the gastrointestinal tract.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.2008.00454.x