Predictors of post‐thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency

• Published in: Journal of thrombosis and haemostasis 2013-03, Vol.11 (3), p.474-480
• Main Authors: Galanaud, J. P., Holcroft, C. A., Rodger, M. A., Kovacs, M. J., Betancourt, M. T., Wells, P. S., Anderson, D. R., Chagnon, I., Gal, G., Solymoss, S., Crowther, M. A., Perrier, A., White, R. H., Vickars, L. M., Ramsay, T., Kahn, S. R.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anticoagulants; Anticoagulants - therapeutic use; Canada; Canada - epidemiology; Complications; deep vein thrombosis; Dilatation, Pathologic; Drug Monitoring; Drug Monitoring - methods; Europe; Europe - epidemiology; Female; Humans; International Normalized Ratio; Life Sciences; Male; Middle Aged; Multivariate Analysis; Obesity; Obesity - epidemiology; Odds Ratio; Postthrombotic Syndrome; Postthrombotic Syndrome - diagnosis; Postthrombotic Syndrome - drug therapy; Postthrombotic Syndrome - epidemiology; post‐thrombotic syndrome; Predictive Value of Tests; Prevalence; Prevention; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Thromboembolism; Time Factors; United States; United States - epidemiology; Veins; Veins - pathology; Venous Insufficiency; Venous Insufficiency - epidemiology; venous thromboembolism; Venous Thrombosis; Venous Thrombosis - diagnosis; Venous Thrombosis - drug therapy; Venous Thrombosis - epidemiology; Villalta scale
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/jth.12106

Summary Background Post‐thrombotic syndrome (PTS) is the most frequent complication of deep vein thrombosis (DVT). Its diagnosis is based on clinical characteristics. However, symptoms and signs of PTS are non‐specific, and could result from concomitant primary venous insufficiency (PVI) rather than DVT. This could bias evaluation of PTS. Methods Using data from the REVERSE multicenter study, we assessed risk factors for PTS in patients with a first unprovoked unilateral proximal DVT 5–7 months earlier who were free of clinically significant PVI (defined as absence of moderate or severe venous ectasia in the contralateral leg). Results Among the 328 patients considered, the prevalence of PTS was 27.1%. Obesity (odds ratio [OR] 2.6 [95% confidence interval (CI) 1.5–4.7]), mild contralateral venous ectasia (OR 2.2 [95% CI 1.1–4.3]), poor International Normalized Ratio (INR) control (OR per additional 1% of time with INR