Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans

Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implic...

Full description

Saved in:
Bibliographic Details
Published in:Journal of developmental origins of health and disease 2013-04, Vol.4 (2), p.134-138
Main Authors: Mayeur, S., Cisse, O., Gabory, A., Barbaux, S., Vaiman, D., Vambergue, A., Fajardy, I., Deloof, S., Junien, C., Laborie, C., Vieau, D., Lesage, J.
Format: Article
Language:English
Subjects:
Accreditation
Birth weight
Brief Report
Carbohydrates
Development Biology
Diabetes
DNA methylation
Epigenetics
Fetuses
Gene expression
Genomes
Life Sciences
Metabolism
Mutation
Nutrition research
Obesity
Placenta
Pregnancy
Proteins
Reproductive Biology
Rodents
Software
Trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its placental expression in samples including extremes of abnormal fetal growth, such as after intrauterine growth restriction (IUGR) or macrosomia in both rats and humans. In rats, fetal growth was modulated by maternal nutritional modifications. In humans, placental villi were collected from pathological pregnancies (i.e. with IUGR or fetal macrosomia). Placental FTO mRNA expression was reduced by IUGR but was not significantly affected by macrosomia in either rats or humans. Our data suggest that placental FTO may participate in interactions between the in utero environment and the control of fetal growth under IUGR conditions by modulating epigenetic processes.
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174412000748