Current role of CT and whole body MRI in multiple myeloma

Abstract Radiology of bone lacunae can help differentiate between smouldering and symptomatic myeloma. CT seems to be more apt for this purpose than a standard X-ray but appropriate principles must be applied when performing and reading it. Lesions visible in an MRI above all allow myelomas to be mo...

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Bibliographic Details
Published in:Diagnostic and interventional imaging 2013-02, Vol.94 (2), p.169-183
Main Authors: Duvauferrier, R, Valence, M, Patrat-Delon, S, Brillet, E, Niederberger, E, Marchand, A, Rescan, M, Guillin, R, Decaux, O
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Bone Neoplasms - diagnosis
Diffusion Magnetic Resonance Imaging
Diffusion-weighted MRI
Female
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted
Life Sciences
Low dose whole body CT
Magnetic Resonance Imaging
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - blood
Multiple Myeloma - diagnosis
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - pathology
Positron-Emission Tomography
Radiation Dosage
Radiology
Retrospective Studies
Tomography, X-Ray Computed
Whole Body Imaging
Whole body MRI
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Summary:Abstract Radiology of bone lacunae can help differentiate between smouldering and symptomatic myeloma. CT seems to be more apt for this purpose than a standard X-ray but appropriate principles must be applied when performing and reading it. Lesions visible in an MRI above all allow myelomas to be monitored during treatment. Because of the radiation dose, whole body CT must be performed with a slice thickness of 2 mm, increments of 1.5 and intensity of 40 mAs. It should be read associating the reading of the axial slices with reading the mean coronal and sagittal projections of a thickness of 2 cm. Whole body MRI must associate T1-weighted sagittal, STIR coronal and b-800 diffusion-weighted axial sequences. Changes in the disease correlate with changes in the diffusion, STIR and T1-weighted images interpreted together. While whole body CT has a place in clinical routine, the indication for whole body MRI still needs to be clarified and has yet to take its place in research protocols.
ISSN:2211-5684
2211-5684
DOI:10.1016/j.diii.2012.12.001