Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in anima...

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Bibliographic Details
Published in:Molecular neurobiology 2016-09, Vol.53 (7), p.4874-4882
Main Authors: Alcocer-Gómez, Elísabet, Ulecia-Morón, Cristina, Marín-Aguilar, Fabiola, Rybkina, Tatyana, Casas-Barquero, Nieves, Ruiz-Cabello, Jesús, Ryffel, Bernhard, Apetoh, Lionel, Ghiringhelli, François, Bullón, Pedro, Sánchez-Alcazar, José Antonio, Carrión, Angel M., Cordero, Mario D.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Depression - metabolism
Depression - pathology
Depression - psychology
Hippocampus - metabolism
Hippocampus - pathology
Inflammasomes - deficiency
Interpersonal Relations
Life Sciences
Male
Mental depression
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia - metabolism
Microglia - pathology
Neurobiology
Neurology
Neurons and Cognition
Neurosciences
NLR Family, Pyrin Domain-Containing 3 Protein - deficiency
Oxidative stress
Prefrontal Cortex - metabolism
Prefrontal Cortex - pathology
Public health
Stress, Psychological - metabolism
Stress, Psychological - pathology
Stress, Psychological - psychology
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Summary:Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-015-9408-7