Three-dimensional right-ventricular regional deformation and survival in pulmonary hypertension

Abstract Aims Survival in pulmonary hypertension (PH) relates to right ventricular (RV) function. However, the RV unique anatomy and structure limit 2D analysis and its regional 3D function has not been studied yet. The aim of this study was to assess the implications of global and regional 3D RV de...

Full description

Saved in:
Bibliographic Details
Published in:European heart journal cardiovascular imaging 2018-04, Vol.19 (4), p.450-458
Main Authors: Moceri, Pamela, Duchateau, Nicolas, Baudouy, Delphine, Schouver, Elie-Dan, Leroy, Sylvie, Squara, Fabien, Ferrari, Emile, Sermesant, Maxime
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Area Under Curve
Cardiac Catheterization - methods
Case-Control Studies
Computer Science
Echocardiography - methods
Echocardiography, Three-Dimensional - methods
Female
France
Humans
Hypertension, Pulmonary - diagnostic imaging
Hypertension, Pulmonary - mortality
Hypertension, Pulmonary - physiopathology
Image Processing, Computer-Assisted
Longitudinal Studies
Male
Medical Imaging
Middle Aged
Multivariate Analysis
Prognosis
Reference Values
Severity of Illness Index
Statistics, Nonparametric
Stroke Volume - physiology
Survival Rate
Ventricular Dysfunction, Right - diagnostic imaging
Ventricular Dysfunction, Right - mortality
Ventricular Dysfunction, Right - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aims Survival in pulmonary hypertension (PH) relates to right ventricular (RV) function. However, the RV unique anatomy and structure limit 2D analysis and its regional 3D function has not been studied yet. The aim of this study was to assess the implications of global and regional 3D RV deformation on clinical condition and survival in adults with PH and healthy controls. Methods and results We collected a prospective longitudinal cohort of 104 consecutive PH patients and 34 healthy controls between September 2014 and December 2015. Acquired 3D transthoracic RV echocardiographic sequences were analysed by semi-automatic software (TomTec 4D RV-Function 2.0). Output meshes were post-processed to extract regional motion and deformation. Global and regional statistics provided deformation patterns for each subgroup of subjects. RV lateral and inferior regions showed the highest deformation. In PH patients, RV global and regional motion and deformation [both circumferential, longitudinal, and area strain (AS)] were affected in all segments (P  −18% was the most powerful RV function parameter, identifying patients with a 48%-increased risk of death (AUC 0.83 [0.74–0.90], P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jex163