Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling

The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field...

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Published in:Ecotoxicology and environmental safety 2018-03, Vol.149, p.284-290
Main Authors: Bertin, Delphine, Ferrari, Benoît J.D., Labadie, Pierre, Sapin, Alexandre, Da Silva Avelar, Débora, Beaudouin, Rémy, Péry, Alexandre, Garric, Jeanne, Budzinski, Hélène, Babut, Marc
Format: Article
Language:English
Subjects:
Animals
Bioaccumulation
Chironomidae - metabolism
Chironomus riparius
Concentration-dependency
Dose-Response Relationship, Drug
Fluorocarbons - metabolism
Geologic Sediments - chemistry
Larva - metabolism
Life Sciences
Models, Theoretical
Per- and polyfluoroalkyl substances
Perfluorotridecanoic acid
Uptake rate
Water Pollutants, Chemical - metabolism
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Summary:The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field sediments collected downstream of a fluorotelomer plant, and to the same sediment spiked with PFTrDA. Elimination kinetics results indicated complete elimination of all PFASs by chironomids after 42h. These data were used to develop two PFTrDA bioaccumulation models accounting for chironomid growth and for compound concentration dependency or not. There was much better agreement between observed and simulated data under the concentration-dependency hypothesis than under the alternative one (passive diffusion). The PFTrDA uptake rate derived from the concentration-dependency model equaled 0.013 ± 0.008gocgwwh−1, and the depuration rate 0.032 ± 0.009h−1. [Display omitted] •Chironomids were exposed to sediment contaminated by fluoro-alkyl substances.•For all compounds, nearly complete elimination from tissues was achieved in 42h.•Modelling shows that PFTrDA uptake is concentration-dependent.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2017.12.011