Molecular surveillance of norovirus, 2005–16: an epidemiological analysis of data collected from the NoroNet network

The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. We included genetic sequences of norovirus specimens obtained from outbreak investig...

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Bibliographic Details
Published in:The Lancet infectious diseases 2018-05, Vol.18 (5), p.545-553
Main Authors: van Beek, Janko, de Graaf, Miranda, Al-Hello, Haider, Allen, David J, Ambert-Balay, Katia, Botteldoorn, Nadine, Brytting, Mia, Buesa, Javier, Cabrerizo, Maria, Chan, Martin, Cloak, Fiona, Di Bartolo, Ilaria, Guix, Susana, Hewitt, Joanne, Iritani, Nobuhiro, Jin, Miao, Johne, Reimar, Lederer, Ingeborg, Mans, Janet, Martella, Vito, Maunula, Leena, McAllister, Georgina, Niendorf, Sandra, Niesters, Hubert G, Podkolzin, Alexander T, Poljsak-Prijatelj, Mateja, Rasmussen, Lasse Dam, Reuter, Gábor, Tuite, Gráinne, Kroneman, Annelies, Vennema, Harry, Koopmans, Marion P G
Format: Article
Language:English
Subjects:
Analysis
Clinical trials
Collaboration
Consortia
Data processing
Drift
Epidemiology
Evolution
Gastroenteritis
Gene sequencing
Genetic analysis
Genetic diversity
Genomes
Genotype & phenotype
Genotypes
Human health and pathology
Hépatology and Gastroenterology
Infectious diseases
Life Sciences
Medical research
Microbiology and Parasitology
Outbreaks
Periodicity
Population
Public health
Recombination
Studies
Surveillance
Trends
Vaccines
Virology
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Summary:The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at open reading frame (ORF) 1 and ORF2. Additionally, we assessed the sampling date and country of origin of the first reported sequence to assess when and where novel drift variants originated. We analysed 16 635 norovirus sequences submitted between Jan 1, 2005, to Nov 17, 2016, of which 1372 (8·2%) sequences belonged to genotype GI, 15 256 (91·7%) to GII, and seven (
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(18)30059-8