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Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation
Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to eva...
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| Published in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2018-04, Vol.37 (2), p.739-745 |
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| creator | Brotelle, Thibault Lemal, Richard Cabrespine, Aurélie Combal, Cécile Hermet, Eric Ravinet, Aurélie Bay, Jacques-Olivier Bouteloup, Corinne |
| description | Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to evaluate the prevalence of malnutrition in adult patients who underwent allo-HSCT more than one year ago. Secondary objectives were to assess body composition, muscle strength, and factors associated with malnutrition. Patients & methods All allo-HSCT patients admitted into the University Hospital of Clermont-Ferrand between 1st January 1985 and 31st December 2012 were screened. Clinical and biological nutritional assessments included anthropometric measurements, serum nutritional proteins, body composition assessed by bioelectrical impedance, and upper-limb muscle strength (MS) measured by dynamometry. Hematological and nutritional data during and after hospital stay for allo-HSCT were retrospectively collected. Results Eighty four allo-HSCT patients (52% men; mean age 54.4 ± 12.5 years) were enrolled. Average follow-up after allo-HSCT was 56.4 ± 47.5 months. Prevalence of malnutrition at the end of follow-up was 20%. Compared to well-nourished patients (WN group), undernourished patients (UN group) at the end of follow-up were significantly more likely to be undernourished (50% vs. 21%, p = 0.04) at hospital admission, and to have a Nutritional Risk Index of |
| doi_str_mv | 10.1016/j.clnu.2017.03.016 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01760519v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0261561417301073</els_id><sourcerecordid>1886359942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-d79a8f1051c835e0f1fd15b52d614cca23c98b5d1159097d3a718c56fdcf35073</originalsourceid><addsrcrecordid>eNp9kkGO1DAQRSMEYpqBC7BAWcIiwRXHiSMhpNEIGKSWQALWltuu0G4cO9hOQ9-Gs3AyHPUwCxasLJf-f3bVr6J4CqQGAt3LQ62sW-qGQF8TWufSvWIDjDYVDJzeLzak6aBiHbQXxaMYD4QQRnv-sLhoOB0Ib9mm-Pkx4FFadApLP5aTzMQUTDLelcaVUi82lbNMBl2K5ZzFxi_RnsoUUCbU5Q-T9r9_SWv9V3RoVLnHSSY_e4Mp32LCqVJobTZIF2crXZIr_XHxYJQ24pPb87L48vbN5-ubavvh3fvrq22l2palSveD5CMQBopThmSEUQPbsUbntpSSDVUD3zENwAYy9JrKHrhi3ajVSBnp6WXx4szdSyvmYCYZTsJLI26utmKt5el1GT8cIWufn7Vz8N8XjElMJq6flw5z1wI47ygbhrbJ0uYsVcHHGHC8YwMRazriINZ0xJqOIDQ_02XTs1v-sptQ31n-xpEFr84CzBM5GgwiKrNmo01AlYT25v_81__YlTXOKGm_4QnjwS_B5VkLELERRHxa92NdD-gpgTwr-gcSVrie</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886359942</pqid></control><display><type>article</type><title>Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation</title><source>Elsevier</source><creator>Brotelle, Thibault ; Lemal, Richard ; Cabrespine, Aurélie ; Combal, Cécile ; Hermet, Eric ; Ravinet, Aurélie ; Bay, Jacques-Olivier ; Bouteloup, Corinne</creator><creatorcontrib>Brotelle, Thibault ; Lemal, Richard ; Cabrespine, Aurélie ; Combal, Cécile ; Hermet, Eric ; Ravinet, Aurélie ; Bay, Jacques-Olivier ; Bouteloup, Corinne</creatorcontrib><description>Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to evaluate the prevalence of malnutrition in adult patients who underwent allo-HSCT more than one year ago. Secondary objectives were to assess body composition, muscle strength, and factors associated with malnutrition. Patients & methods All allo-HSCT patients admitted into the University Hospital of Clermont-Ferrand between 1st January 1985 and 31st December 2012 were screened. Clinical and biological nutritional assessments included anthropometric measurements, serum nutritional proteins, body composition assessed by bioelectrical impedance, and upper-limb muscle strength (MS) measured by dynamometry. Hematological and nutritional data during and after hospital stay for allo-HSCT were retrospectively collected. Results Eighty four allo-HSCT patients (52% men; mean age 54.4 ± 12.5 years) were enrolled. Average follow-up after allo-HSCT was 56.4 ± 47.5 months. Prevalence of malnutrition at the end of follow-up was 20%. Compared to well-nourished patients (WN group), undernourished patients (UN group) at the end of follow-up were significantly more likely to be undernourished (50% vs. 21%, p = 0.04) at hospital admission, and to have a Nutritional Risk Index of <97.5 (47% vs. 20%, p = 0.004). Compared to a reference population, mid-arm muscle circumference and MS were significantly more likely to be decreased in the UN group than in the WN group (35.3% vs. 8.9%, p = 0.017; 24% vs. 3%, p = 0.005, respectively); fat-free mass index and appendicular skeletal muscle mass index were decreased in 30.5% and 36.6% of all patients, respectively, with no difference between UN and WN groups. Chronic graft-versus-host disease was more frequent, although not significantly in the UN group (76% vs. 52%, p = 0.071). In multivariate analyses, the presence of malnutrition at hospital admission for allo-HSCT trended towards an increased risk of longer-term malnutrition (OR = 3.60 [0.95; 13.67], p = 0.06). Conclusion Malnutrition is a frequent consequence of allo-HSCT, and may occur several months or years after allo-HSCT, particularly if malnutrition existed before allo-HSCT. Our findings support the need for specialized nutritional care for both before and after allo-HSCT. Furthermore, assessment of muscle mass may be a pertinent parameter of malnutrition in this instance.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2017.03.016</identifier><identifier>PMID: 28390845</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Body composition ; Cohort Studies ; Female ; Gastroenterology and Hepatology ; Hemato-oncology ; Hematology ; Hematopoietic Stem Cell Transplantation ; Human health and pathology ; Humans ; Life Sciences ; Male ; Malnutrition - diagnosis ; Malnutrition - epidemiology ; Middle Aged ; Muscle mass ; Muscle strength ; Nutrition Assessment ; Nutritional Status ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Prevalence</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2018-04, Vol.37 (2), p.739-745</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-d79a8f1051c835e0f1fd15b52d614cca23c98b5d1159097d3a718c56fdcf35073</citedby><cites>FETCH-LOGICAL-c445t-d79a8f1051c835e0f1fd15b52d614cca23c98b5d1159097d3a718c56fdcf35073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28390845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01760519$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brotelle, Thibault</creatorcontrib><creatorcontrib>Lemal, Richard</creatorcontrib><creatorcontrib>Cabrespine, Aurélie</creatorcontrib><creatorcontrib>Combal, Cécile</creatorcontrib><creatorcontrib>Hermet, Eric</creatorcontrib><creatorcontrib>Ravinet, Aurélie</creatorcontrib><creatorcontrib>Bay, Jacques-Olivier</creatorcontrib><creatorcontrib>Bouteloup, Corinne</creatorcontrib><title>Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to evaluate the prevalence of malnutrition in adult patients who underwent allo-HSCT more than one year ago. Secondary objectives were to assess body composition, muscle strength, and factors associated with malnutrition. Patients & methods All allo-HSCT patients admitted into the University Hospital of Clermont-Ferrand between 1st January 1985 and 31st December 2012 were screened. Clinical and biological nutritional assessments included anthropometric measurements, serum nutritional proteins, body composition assessed by bioelectrical impedance, and upper-limb muscle strength (MS) measured by dynamometry. Hematological and nutritional data during and after hospital stay for allo-HSCT were retrospectively collected. Results Eighty four allo-HSCT patients (52% men; mean age 54.4 ± 12.5 years) were enrolled. Average follow-up after allo-HSCT was 56.4 ± 47.5 months. Prevalence of malnutrition at the end of follow-up was 20%. Compared to well-nourished patients (WN group), undernourished patients (UN group) at the end of follow-up were significantly more likely to be undernourished (50% vs. 21%, p = 0.04) at hospital admission, and to have a Nutritional Risk Index of <97.5 (47% vs. 20%, p = 0.004). Compared to a reference population, mid-arm muscle circumference and MS were significantly more likely to be decreased in the UN group than in the WN group (35.3% vs. 8.9%, p = 0.017; 24% vs. 3%, p = 0.005, respectively); fat-free mass index and appendicular skeletal muscle mass index were decreased in 30.5% and 36.6% of all patients, respectively, with no difference between UN and WN groups. Chronic graft-versus-host disease was more frequent, although not significantly in the UN group (76% vs. 52%, p = 0.071). In multivariate analyses, the presence of malnutrition at hospital admission for allo-HSCT trended towards an increased risk of longer-term malnutrition (OR = 3.60 [0.95; 13.67], p = 0.06). Conclusion Malnutrition is a frequent consequence of allo-HSCT, and may occur several months or years after allo-HSCT, particularly if malnutrition existed before allo-HSCT. Our findings support the need for specialized nutritional care for both before and after allo-HSCT. Furthermore, assessment of muscle mass may be a pertinent parameter of malnutrition in this instance.</description><subject>Body composition</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Hemato-oncology</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Malnutrition - diagnosis</subject><subject>Malnutrition - epidemiology</subject><subject>Middle Aged</subject><subject>Muscle mass</subject><subject>Muscle strength</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Prevalence</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kkGO1DAQRSMEYpqBC7BAWcIiwRXHiSMhpNEIGKSWQALWltuu0G4cO9hOQ9-Gs3AyHPUwCxasLJf-f3bVr6J4CqQGAt3LQ62sW-qGQF8TWufSvWIDjDYVDJzeLzak6aBiHbQXxaMYD4QQRnv-sLhoOB0Ib9mm-Pkx4FFadApLP5aTzMQUTDLelcaVUi82lbNMBl2K5ZzFxi_RnsoUUCbU5Q-T9r9_SWv9V3RoVLnHSSY_e4Mp32LCqVJobTZIF2crXZIr_XHxYJQ24pPb87L48vbN5-ubavvh3fvrq22l2palSveD5CMQBopThmSEUQPbsUbntpSSDVUD3zENwAYy9JrKHrhi3ajVSBnp6WXx4szdSyvmYCYZTsJLI26utmKt5el1GT8cIWufn7Vz8N8XjElMJq6flw5z1wI47ygbhrbJ0uYsVcHHGHC8YwMRazriINZ0xJqOIDQ_02XTs1v-sptQ31n-xpEFr84CzBM5GgwiKrNmo01AlYT25v_81__YlTXOKGm_4QnjwS_B5VkLELERRHxa92NdD-gpgTwr-gcSVrie</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Brotelle, Thibault</creator><creator>Lemal, Richard</creator><creator>Cabrespine, Aurélie</creator><creator>Combal, Cécile</creator><creator>Hermet, Eric</creator><creator>Ravinet, Aurélie</creator><creator>Bay, Jacques-Olivier</creator><creator>Bouteloup, Corinne</creator><general>Elsevier Ltd</general><general>Elsevier / European Society for Clinical Nutrition and Metabolism</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20180401</creationdate><title>Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation</title><author>Brotelle, Thibault ; Lemal, Richard ; Cabrespine, Aurélie ; Combal, Cécile ; Hermet, Eric ; Ravinet, Aurélie ; Bay, Jacques-Olivier ; Bouteloup, Corinne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-d79a8f1051c835e0f1fd15b52d614cca23c98b5d1159097d3a718c56fdcf35073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Body composition</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Hemato-oncology</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Malnutrition - diagnosis</topic><topic>Malnutrition - epidemiology</topic><topic>Middle Aged</topic><topic>Muscle mass</topic><topic>Muscle strength</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brotelle, Thibault</creatorcontrib><creatorcontrib>Lemal, Richard</creatorcontrib><creatorcontrib>Cabrespine, Aurélie</creatorcontrib><creatorcontrib>Combal, Cécile</creatorcontrib><creatorcontrib>Hermet, Eric</creatorcontrib><creatorcontrib>Ravinet, Aurélie</creatorcontrib><creatorcontrib>Bay, Jacques-Olivier</creatorcontrib><creatorcontrib>Bouteloup, Corinne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brotelle, Thibault</au><au>Lemal, Richard</au><au>Cabrespine, Aurélie</au><au>Combal, Cécile</au><au>Hermet, Eric</au><au>Ravinet, Aurélie</au><au>Bay, Jacques-Olivier</au><au>Bouteloup, Corinne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>37</volume><issue>2</issue><spage>739</spage><epage>745</epage><pages>739-745</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to evaluate the prevalence of malnutrition in adult patients who underwent allo-HSCT more than one year ago. Secondary objectives were to assess body composition, muscle strength, and factors associated with malnutrition. Patients & methods All allo-HSCT patients admitted into the University Hospital of Clermont-Ferrand between 1st January 1985 and 31st December 2012 were screened. Clinical and biological nutritional assessments included anthropometric measurements, serum nutritional proteins, body composition assessed by bioelectrical impedance, and upper-limb muscle strength (MS) measured by dynamometry. Hematological and nutritional data during and after hospital stay for allo-HSCT were retrospectively collected. Results Eighty four allo-HSCT patients (52% men; mean age 54.4 ± 12.5 years) were enrolled. Average follow-up after allo-HSCT was 56.4 ± 47.5 months. Prevalence of malnutrition at the end of follow-up was 20%. Compared to well-nourished patients (WN group), undernourished patients (UN group) at the end of follow-up were significantly more likely to be undernourished (50% vs. 21%, p = 0.04) at hospital admission, and to have a Nutritional Risk Index of <97.5 (47% vs. 20%, p = 0.004). Compared to a reference population, mid-arm muscle circumference and MS were significantly more likely to be decreased in the UN group than in the WN group (35.3% vs. 8.9%, p = 0.017; 24% vs. 3%, p = 0.005, respectively); fat-free mass index and appendicular skeletal muscle mass index were decreased in 30.5% and 36.6% of all patients, respectively, with no difference between UN and WN groups. Chronic graft-versus-host disease was more frequent, although not significantly in the UN group (76% vs. 52%, p = 0.071). In multivariate analyses, the presence of malnutrition at hospital admission for allo-HSCT trended towards an increased risk of longer-term malnutrition (OR = 3.60 [0.95; 13.67], p = 0.06). Conclusion Malnutrition is a frequent consequence of allo-HSCT, and may occur several months or years after allo-HSCT, particularly if malnutrition existed before allo-HSCT. Our findings support the need for specialized nutritional care for both before and after allo-HSCT. Furthermore, assessment of muscle mass may be a pertinent parameter of malnutrition in this instance.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28390845</pmid><doi>10.1016/j.clnu.2017.03.016</doi><tpages>7</tpages></addata></record> |
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| subjects | Body composition Cohort Studies Female Gastroenterology and Hepatology Hemato-oncology Hematology Hematopoietic Stem Cell Transplantation Human health and pathology Humans Life Sciences Male Malnutrition - diagnosis Malnutrition - epidemiology Middle Aged Muscle mass Muscle strength Nutrition Assessment Nutritional Status Postoperative Complications - diagnosis Postoperative Complications - epidemiology Prevalence |
| title | Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation |
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