Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

In this study, we have compared the severity of amyloid plaque formation and cerebral amyloid angiopathy (CAA), and the subtype pattern of CAA pathology itself, between APP genetic causes of AD ( APP dup, APP mutations), older individuals with Down syndrome (DS) showing the pathology of Alzheimer’s...

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Bibliographic Details
Published in:	Acta neuropathologica 2018-10, Vol.136 (4), p.569-587
Main Authors:	Mann, David M. A., Davidson, Yvonne S., Robinson, Andrew C., Allen, Nancy, Hashimoto, Tadafumi, Richardson, Anna, Jones, Matthew, Snowden, Julie S., Pendleton, Neil, Potier, Marie-Claude, Laquerrière, Annie, Prasher, Vee, Iwatsubo, Takeshi, Strydom, Andre
Format:	Article
Language:	English
Subjects:	Adult Advertising executives Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid - metabolism Amyloid beta-Protein Precursor - genetics Amyloid precursor protein Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Arteries Blood Vessels - metabolism Capillaries Cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - genetics Cerebral Amyloid Angiopathy - pathology Cholesterol Down syndrome Down Syndrome - genetics Down Syndrome - pathology Down's syndrome Female Gene Duplication Gene Frequency Genetic aspects Genetic research Genotype Genotypes Humans Life Sciences Lipid metabolism Male Medical schools Medicine Medicine & Public Health Middle Aged Missense mutation Mutation Mutation, Missense Neurobiology Neurons and Cognition Neurosciences Original Paper Pathology Physiological aspects Plaque, Amyloid - genetics Plaque, Amyloid - pathology Vascular diseases
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