Increased factor VIII plays a significant role in plasma hypercoagulability phenotype of patients with cirrhosis

Summary Essentials The role of increased factor VIII in cirrhosis‐induced hypercoagulability has never been demonstrated. Factor VIII and protein C effects were characterized by thrombin generation with thrombomodulin. Factor VIII elevation plays a significant role in cirrhosis‐induced plasma hyperc...

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Published in:Journal of thrombosis and haemostasis 2018-06, Vol.16 (6), p.1132-1140
Main Authors: Sinegre, T., Duron, C., Lecompte, T., Pereira, B., Massoulier, S., Lamblin, G., Abergel, A., Lebreton, A.
Format: Article
Language:English
Subjects:
Cardiology and cardiovascular system
Cirrhosis
Coagulation factors
factor VIII
Human health and pathology
hypercoagulability
Life Sciences
Liver cirrhosis
Phenotypes
Phospholipids
Protein C
Protein deficiency
protein C
Thrombin
thrombin generation
Thrombomodulin
Tissue factor
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Summary:Summary Essentials The role of increased factor VIII in cirrhosis‐induced hypercoagulability has never been demonstrated. Factor VIII and protein C effects were characterized by thrombin generation with thrombomodulin. Factor VIII elevation plays a significant role in cirrhosis‐induced plasma hypercoagulability. Only protein C and factor VIII normalization led to thrombin generation similar to controls. Summary Background In cirrhosis, thrombin generation (TG) studied in the presence of thrombomodulin (TM) indicates plasma hypercoagulability. Although the role of protein C (PC) deficiency has been investigated, the influence of an increase in the factor VIII level has never been addressed. Objectives We investigated the roles of high FVIII and low PC levels in increased TG in the presence of TM. Methods Blood samples were prospectively collected from 35 healthy controls and 93 patients with cirrhosis (Child–Turcotte–Pugh [CTP]‐A, n = 61; CTP‐B, n = 19; and CTP‐C, n = 13) and FVIII levels > 150% (n = 48) and/or PC levels
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.14011