Stimuli-responsive magnetic particles for biomedical applications

An ideal stimuli-responsive magnetic system possibilities the monitoring of the medication in the organism followed by the treatment using local drug delivery or hyperthermia. In recent years, magnetic nanoparticles have been studied due to their potential applications as magnetic carriers in biomed...

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Bibliographic Details
Published in:International journal of pharmaceutics 2011-01, Vol.403 (1-2), p.139-161
Main Authors: Medeiros, S.F., Santos, A.M., Fessi, H., Elaissari, A.
Format: Article
Language:English
Subjects:
Animals
Applications
Biological and medical sciences
Biomedical
Chemical and Process Engineering
Coated Materials, Biocompatible - chemistry
Drug Delivery Systems - trends
Engineering Sciences
Ferrofluid
fever
gels
General pharmacology
Humans
Hydrogen-Ion Concentration
Life Sciences
Magnetic nanoparticles
magnetic properties
magnetic resonance imaging
Magnetic Resonance Imaging - trends
Magnetics
Medical sciences
N-vinylcaprolactam
Nanomedicine - trends
nanoparticles
Nanoparticles - chemistry
Pharmaceutical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phase Transition
polymers
Polymers - chemistry
Smart polymers
surveys
Temperature
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Summary:An ideal stimuli-responsive magnetic system possibilities the monitoring of the medication in the organism followed by the treatment using local drug delivery or hyperthermia. In recent years, magnetic nanoparticles have been studied due to their potential applications as magnetic carriers in biomedical area. These materials have been increasingly exploited as efficient delivery vectors, leading to opportunities of use as magnetic resonance imaging (MRI) agents, mediators of hyperthermia cancer treatment and in targeted therapies. Much attention has been also focused on “smart” polymers, which are able to respond to environmental changes, such as changes in the temperature and pH. In this context, this article reviews the state-of-the art in stimuli-responsive magnetic systems for biomedical applications. The paper describes different types of stimuli-sensitive systems, mainly temperature- and pH sensitive polymers, the combination of this characteristic with magnetic properties and, finally, it gives an account of their preparation methods. The article also discusses the main in vivo biomedical applications of such materials. A survey of the recent literature on various stimuli-responsive magnetic gels in biomedical applications is also included.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2010.10.011