Integrin-mediated adhesion as self-sustained waves of enzymatic activation

Integrin receptors mediate interaction between the cellular actin-cytoskeleton and extracellular matrix. Based on their activation properties, we propose a reaction-diffusion model where the kinetics of the two-state receptors is modulated by their lipidic environment. This environment serves as an...

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Bibliographic Details
Published in:Physical review. E, Statistical, nonlinear, and soft matter physics Statistical, nonlinear, and soft matter physics, 2015-10, Vol.92 (4), p.042704-042704, Article 042704
Main Authors: Block, M R, Destaing, O, Petropoulos, C, Planus, E, Albigès-Rizo, C, Fourcade, B
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Cell Adhesion - physiology
Computer Simulation
Condensed Matter
Diffusion
Enzyme Activation - physiology
Integrins - metabolism
Kinetics
Models, Biological
Physics
Soft Condensed Matter
Statistical Mechanics
Stochastic Processes
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Summary:Integrin receptors mediate interaction between the cellular actin-cytoskeleton and extracellular matrix. Based on their activation properties, we propose a reaction-diffusion model where the kinetics of the two-state receptors is modulated by their lipidic environment. This environment serves as an activator variable, while a second variable plays the role of a scaffold protein and controls the self-sustained activation of the receptors. Due to receptor diffusion which couples dynamically the activator and the inhibitor, our model connects major classes of reaction diffusion systems for excitable media. Spot and rosette solutions, characterized by receptor clustering into localized static or dynamic structures, are organized into a phase diagram. It is shown that diffusion and kinetics of receptors determines the dynamics and the stability of these structures. We discuss this model as a precursor model for cell signaling in the context of podosomes forming actoadhesive metastructures, and we study how generic signaling defects influence their organization.
ISSN:1539-3755
1550-2376
DOI:10.1103/PhysRevE.92.042704