Nucleolin: Dual roles in rDNA chromatin transcription

Nucleolin is a major nucleolar protein conserved in all eukaryotic organisms. It is a multifunctional protein involved in different cellular aspects like chromatin organization and stability, DNA and RNA metabolism, assembly of ribonucleoprotein complexes, cytokinesis, cell proliferation and stress...

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Bibliographic Details
Published in:Gene 2015-02, Vol.556 (1), p.7-12
Main Authors: Durut, Nathalie, Sáez-Vásquez, Julio
Format: Article
Language:English
Subjects:
Animals
Chromatin
Chromatin - genetics
Chromatin - metabolism
DNA, Ribosomal - genetics
DNA, Ribosomal - metabolism
Epigenetics
Gene Expression Regulation
Genes, rRNA
Humans
Life Sciences
Nucleolin
Nucleolus
Phosphoproteins - physiology
rDNA
RNA pol I
RNA Polymerase I - physiology
RNA-Binding Proteins - physiology
Transcription, Genetic - genetics
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Summary:Nucleolin is a major nucleolar protein conserved in all eukaryotic organisms. It is a multifunctional protein involved in different cellular aspects like chromatin organization and stability, DNA and RNA metabolism, assembly of ribonucleoprotein complexes, cytokinesis, cell proliferation and stress response. The multifunctionality of nucleolin is linked to its tripartite structure, post-translational modifications and its ability of shuttling from and to the nucleolus/nucleoplasm and cytoplasm. Nucleolin has been now studied for many years and its activities and properties have been described in a number of excellent reviews. Here, we overview the role of nucleolin in RNA polymerase I (RNAPI) transcription and describe recent results concerning its functional interaction with rDNA chromatin organization. For a long time, nucleolin has been associated with rRNA gene expression and pre-rRNA processing. However, the functional connection between nucleolin and active versus inactive rRNA genes is still not fully understood. Novel evidence indicates that the nucleolin protein might be required for controlling the transcriptional ON/OFF states of rDNA chromatin in both mammals and plants. •Effect of nucleolin protein from animal and plant cells on 45 rDNA dynamics•Nucleolin is required for maintenance of rDNA and histone epigenetic marks.•Functional connection between nucleolin and active versus inactive rDNA•Coupling rRNA transcription and processing
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2014.09.023