History of tRNA research in strasbourg

The tRNA molecules, in addition to translating the genetic code into protein and defining the second genetic code via their aminoacylation by aminoacyl‐tRNA synthetases, act in many other cellular functions and dysfunctions. This article, illustrated by personal souvenirs, covers the history of ~60 ...

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Bibliographic Details
Published in:IUBMB life 2019-08, Vol.71 (8), p.1066-1087
Main Authors: Florentz, Catherine, Giegé, Richard
Format: Article
Language:English
Subjects:
Amino Acyl-tRNA Synthetases - metabolism
Aminoacylation
Animals
Biochemistry, Molecular Biology
Biomedical Research - history
Biomedical Research - trends
Chloroplasts - metabolism
epistemology
evolution
France
Genetic Code
history
History, 20th Century
History, 21st Century
Humans
Insecta
Interdisciplinary Research
Life Sciences
Organelles
Polyphosphates - metabolism
Proteomics
Ribonuclease P - metabolism
RNA, Plant - metabolism
RNA, Transfer - metabolism
Strasbourg
structural biology
Structure-function relationships
transfer RNA
translation
tRNA
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Summary:The tRNA molecules, in addition to translating the genetic code into protein and defining the second genetic code via their aminoacylation by aminoacyl‐tRNA synthetases, act in many other cellular functions and dysfunctions. This article, illustrated by personal souvenirs, covers the history of ~60 years tRNA research in Strasbourg. Typical examples point up how the work in Strasbourg was a two‐way street, influenced by and at the same time influencing investigators outside of France. All along, research in Strasbourg has nurtured the structural and functional diversity of tRNA. It produced massive sequence and crystallographic data on tRNA and its partners, thereby leading to a deeper physicochemical understanding of tRNA architecture, dynamics, and identity. Moreover, it emphasized the role of nucleoside modifications and in the last two decades, highlighted tRNA idiosyncrasies in plants and organelles, together with cellular and health‐focused aspects. The tRNA field benefited from a rich local academic heritage and a strong support by both university and CNRS. Its broad interlinks to the worldwide community of tRNA researchers opens to an exciting future. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1066–1087, 2019
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.2079