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Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA
The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences...
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| Published in: | Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (55), p.864-867 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c445t-76211ab94f81920b90ab6f55f74fc7f3a3c0724012ed3f005134c7b2a7dfa6d93 |
| container_end_page | 867 |
| container_issue | 55 |
| container_start_page | 864 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Duchemin, Nicolas Benedetti, Erica Bethge, Lucas Vonhoff, Stefan Klussmann, Sven Vasseur, Jean-Jacques Cossy, Janine Smietana, Michael Arseniyadis, Stellios |
| description | The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.
We report here the first example of an RNA-based catalyst involving a catalytically active metal complex interacting in a non-covalent fashion with short RNA sequences. |
| doi_str_mv | 10.1039/c6cc03540j |
| format | article |
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We report here the first example of an RNA-based catalyst involving a catalytically active metal complex interacting in a non-covalent fashion with short RNA sequences.</description><subject>Alkylation</subject><subject>Asymmetry</subject><subject>Biocatalysis</subject><subject>Biochemistry</subject><subject>Catalysis</subject><subject>Catalysts</subject><subject>Chemical Sciences</subject><subject>Chemists</subject><subject>Gene sequencing</subject><subject>Medicinal Chemistry</subject><subject>Nucleic Acid Conformation</subject><subject>Organic chemistry</subject><subject>Ribonucleic acids</subject><subject>RNA, Catalytic - chemistry</subject><subject>RNA, Catalytic - metabolism</subject><subject>Solvents - chemistry</subject><subject>Transformations</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqN0c9LwzAUB_AgitPpxbvSowrVvPxsj6PMTRkKouCtpGniIu06k07cf2_n5rzuXd4j-fB48EXoDPANYJreaqE1ppzhjz10BFSwmLPkbX818zSWlPEeOg7hA3cFPDlEPSIpkYSRIzQafs_VrHSz96hwzXRZeFfGtSmdak0ZqbCsa9N6pyOtWlUtgwuRm7VN1E5N5I2q6qix0fPj4AQdWFUFc7rpffR6N3zJxvHkaXSfDSaxZoy3sRQEQBUpswmkBBcpVoWwnFvJrJaWKqpxdxgGYkpqMeZAmZYFUbK0SpQp7aOr9d6pqvK5d7Xyy7xRLh8PJvnqDRNIJRHkCzp7ubZz33wuTGjz2gVtqkrNTLMIOSSEd8XYLhRSYBKE2IFiYESIhHb0ek21b0Lwxm4vBpyvosszkWW_0T10-GKzd1F0AWzpX1YdOF8DH_T29z97-gMqx5qw</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Duchemin, Nicolas</creator><creator>Benedetti, Erica</creator><creator>Bethge, Lucas</creator><creator>Vonhoff, Stefan</creator><creator>Klussmann, Sven</creator><creator>Vasseur, Jean-Jacques</creator><creator>Cossy, Janine</creator><creator>Smietana, Michael</creator><creator>Arseniyadis, Stellios</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-8746-9239</orcidid><orcidid>https://orcid.org/0000-0002-4379-6139</orcidid><orcidid>https://orcid.org/0000-0002-6457-7381</orcidid><orcidid>https://orcid.org/0000-0001-6831-2631</orcidid><orcidid>https://orcid.org/0000-0001-8132-7221</orcidid></search><sort><creationdate>20160101</creationdate><title>Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA</title><author>Duchemin, Nicolas ; 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| ispartof | Chemical communications (Cambridge, England), 2016-01, Vol.52 (55), p.864-867 |
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| language | eng |
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| source | Royal Society of Chemistry Journals |
| subjects | Alkylation Asymmetry Biocatalysis Biochemistry Catalysis Catalysts Chemical Sciences Chemists Gene sequencing Medicinal Chemistry Nucleic Acid Conformation Organic chemistry Ribonucleic acids RNA, Catalytic - chemistry RNA, Catalytic - metabolism Solvents - chemistry Transformations |
| title | Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA |
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