Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2018-04, Vol.83 (4), p.402-410
Main Authors: Sall, F. B., Germini, D., Kovina, A. P., Ribrag, V., Wiels, J., Toure, A. O., Iarovaia, O. V., Lipinski, M., Vassetzky, Y.
Format: Article
Language:English
Subjects:
B cells
B-cell lymphoma
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Cell nucleus
Chromosome rearrangements
Chromosome translocations
Deoxyribonucleic acid
DNA
DNA damage
Environmental effects
Environmental factors
Genetic aspects
Genetic research
Genetic transformation
Health aspects
Immunodeficiency
Latex
Life Sciences
Lymphocytes
Lymphocytes B
Lymphomas
Malaria
Microbiology
Nuclear transport
Parasites
Physiological aspects
Review
Translocations (Genetics)
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein–Barr and human immunodeficiency viruses, malaria-causing parasites ( Plasmodium falciparum ), and plant components ( Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918040119