Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats

Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a qui...

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Bibliographic Details
Published in:Psychoneuroendocrinology 1996-07, Vol.21 (5), p.441-453
Main Authors: Dellu, F., Mayo, W., Vallée, M., Maccari, S., Piazza, P.V., Le Moal, M., Simon, H.
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Arousal - physiology
Behavioral psychophysiology
Biological and medical sciences
Cognitive science
Corticosterone - secretion
Fundamental and applied biological sciences. Psychology
Hormones and behavior
HPA axis
Hypothalamo-Hypophyseal System - physiology
Individuality
Inter- and intra-individual differences
Longitudinal Studies
Longitudinal study
Male
Motor Activity - physiology
Neuroscience
Novelty-induced locomotion
Pituitary-Adrenal System - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Sprague-Dawley
Social Environment
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Summary:Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects.
ISSN:0306-4530
1873-3360
DOI:10.1016/0306-4530(96)00017-0