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Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats
Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a qui...
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Published in: | Psychoneuroendocrinology 1996-07, Vol.21 (5), p.441-453 |
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container_issue | 5 |
container_start_page | 441 |
container_title | Psychoneuroendocrinology |
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creator | Dellu, F. Mayo, W. Vallée, M. Maccari, S. Piazza, P.V. Le Moal, M. Simon, H. |
description | Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects. |
doi_str_mv | 10.1016/0306-4530(96)00017-0 |
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Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/0306-4530(96)00017-0</identifier><identifier>PMID: 8888367</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aging ; Aging - physiology ; Animals ; Arousal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Cognitive science ; Corticosterone - secretion ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; HPA axis ; Hypothalamo-Hypophyseal System - physiology ; Individuality ; Inter- and intra-individual differences ; Longitudinal Studies ; Longitudinal study ; Male ; Motor Activity - physiology ; Neuroscience ; Novelty-induced locomotion ; Pituitary-Adrenal System - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cognitive science</subject><subject>Corticosterone - secretion</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>HPA axis</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Individuality</subject><subject>Inter- and intra-individual differences</subject><subject>Longitudinal Studies</subject><subject>Longitudinal study</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Neuroscience</subject><subject>Novelty-induced locomotion</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Social Environment</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp9kc-O0zAQhy0EWrqFNwDJB4R2DwH_SZPmgrSsgEWqxAXO1tgeU6M0LrYTKTceghOPx5PgqFWP-GJ75pufLH-EvODsDWe8ecska6p6I9lN19wyxnhbsUdkxbetrKRs2GOyuiBPyXVKPwrUbBtxRa62ZcmmXZE_73EPkw8RehoRTPaTzzPNgQ5hwr4c7Rj98J3OYcx7CokCPUa0fiGRujIRIg2OphwxpcoPdjRoqQkxexNSxhgGpAlNxOzDQP1A8x4p9hZjP__99Rto7x1W6QhDCRntvCARcnpGnjjoEz4_72vy7eOHr_cP1e7Lp8_3d7vK1ILlSuhGAGDbWosgnOTGOse00Zt6IwQ3LepOc8BOw2YrmNZWcGu5dVZ0rtFarsntKXcPvTpGf4A4qwBePdzt1FJjQgrZdXzihX19Yo8x_BwxZXXwyWDfw4BhTKrd1m3ddm0B6xNoYkgporskc6YWfWpxoxY3qiuXRV8prcnLc_6oD2gvQ2dfpf_q3IdkoHcRBuPTBZOClURRsHcnDMu_TR6jSsbjUMT4iCYrG_z_3_EPVv27jA</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Dellu, F.</creator><creator>Mayo, W.</creator><creator>Vallée, M.</creator><creator>Maccari, S.</creator><creator>Piazza, P.V.</creator><creator>Le Moal, M.</creator><creator>Simon, H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19960701</creationdate><title>Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats</title><author>Dellu, F. ; Mayo, W. ; Vallée, M. ; Maccari, S. ; Piazza, P.V. ; Le Moal, M. ; Simon, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-2b62aae77ddea2f31cdff0bcb545221c7eb9b1ae9ba5820bbd21dd1dfd29f6bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Arousal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cognitive science</topic><topic>Corticosterone - secretion</topic><topic>Fundamental and applied biological sciences. 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Psychophysiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Social Environment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dellu, F.</creatorcontrib><creatorcontrib>Mayo, W.</creatorcontrib><creatorcontrib>Vallée, M.</creatorcontrib><creatorcontrib>Maccari, S.</creatorcontrib><creatorcontrib>Piazza, P.V.</creatorcontrib><creatorcontrib>Le Moal, M.</creatorcontrib><creatorcontrib>Simon, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dellu, F.</au><au>Mayo, W.</au><au>Vallée, M.</au><au>Maccari, S.</au><au>Piazza, P.V.</au><au>Le Moal, M.</au><au>Simon, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>21</volume><issue>5</issue><spage>441</spage><epage>453</epage><pages>441-453</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8888367</pmid><doi>10.1016/0306-4530(96)00017-0</doi><tpages>13</tpages></addata></record> |
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subjects | Aging Aging - physiology Animals Arousal - physiology Behavioral psychophysiology Biological and medical sciences Cognitive science Corticosterone - secretion Fundamental and applied biological sciences. Psychology Hormones and behavior HPA axis Hypothalamo-Hypophyseal System - physiology Individuality Inter- and intra-individual differences Longitudinal Studies Longitudinal study Male Motor Activity - physiology Neuroscience Novelty-induced locomotion Pituitary-Adrenal System - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Sprague-Dawley Social Environment |
title | Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats |
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