Headache changes prior to aneurysmal rupture: A symptom of unruptured aneurysm?

• Published in: Neuro-chirurgie 2016-10, Vol.62 (5), p.241-244
• Main Authors: Gilard, V, Grangeon, L, Guegan-Massardier, E, Sallansonnet-Froment, M, Maltête, D, Derrey, S, Proust, F
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aneurysm, Ruptured - complications; Aneurysm, Ruptured - diagnosis; Aneurysm, Ruptured - surgery; Case-Control Studies; Cerebral aneurysm; Cerebral Angiography - methods; Chronic headache; Female; Headache - diagnosis; Headache - etiology; Headache - physiopathology; Human health and pathology; Humans; Intracranial Aneurysm - therapy; Life Sciences; Male; Middle Aged; Neurosurgery; Retrospective Studies; Sentinel headache; Surgery; Surveys and Questionnaires; Thunderclap headache; Tissues and Organs
• ISSN: 0028-3770; 1773-0619
• DOI: 10.1016/j.neuchi.2016.03.004

Abstract Background and objectives The symptomatic status of unruptured aneurysms has to be looked for. The objective of this retrospective case-control study was to identify the headache semiologic characteristics of symptomatic aneurysms during the 3 months prior to patient admission. Patients and methods The case cohort was composed of 40 consecutive patients admitted for the treatment of a ruptured intracranial aneurysm (IA) and able to answer a standardized questionnaire by the same neurologist. This cohort was matched with a control cohort of 40 patients operated on for a degenerative lumbar pathology. This questionnaire, using the criteria for headache characteristics according to the International Headache Society (IHS) enabled us to classify headaches during the previous 3 months prior to the rupture (study period) and during the year prior to the period studied (reference period) in both cohorts. Headache status was considered as unstable if there were modifications of semiologic headache characteristics, thunderclap headaches or de novo headaches, or on the contrary stable. Results During the status period, chronic headaches were reported by 31 patients (77.5%) in the studied cohort and 35 (87.5%) in the control cohort. During the study period, the cephalagia status was stable in 19 patients (47.5%) versus 35 patients (87.5%) in the control cohort ( P < 0.001). Modifications of chronic headaches were present in 11 patients (35.5%) in the studied cohort versus 4 patients (11.4%) in the control cohort ( P = 0.04). Thunderclap headaches were present in 7 patients (17.5%) in the studied cohort but none in the control cohort ( P = 0.006). Discussion Modifications of headaches semiologic characteristics during the 3 previous months were significantly more frequent in the studied cohort. This modification could be a sign of IA instability.