Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity

Low vitamin B12 and high folate during pregnancy are associated with visceral obesity and insulin resistance in offspring. In the general population, high folate exacerbates the increase of methylmalonic acid, a marker of vitamin B12 deficiency. However, the influence of vitamin B12 and folate and t...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2018-10, Vol.37 (5), p.1700-1706
Main Authors: Li, Zhen, Gueant-Rodriguez, Rosa-Maria, Quilliot, Didier, Sirveaux, Marie-Aude, Meyre, David, Gueant, Jean-Louis, Brunaud, Laurent
Format: Article
Language:English
Subjects:
Adult
Biochemistry, Molecular Biology
Body Mass Index
Endocrinology and metabolism
Erythrocytes - chemistry
Female
Folates
Folic Acid - adverse effects
Folic Acid - blood
Food and Nutrition
HOMA-IR
Homocysteine - blood
Human health and pathology
Humans
Insulin Resistance - physiology
Life Sciences
Male
Metabolic Syndrome - epidemiology
Methylmalonic Acid - blood
Middle Aged
Obesity
Obesity, Morbid - blood
Obesity, Morbid - complications
Vitamin B 12 - blood
Vitamin B 12 Deficiency - complications
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Summary:Low vitamin B12 and high folate during pregnancy are associated with visceral obesity and insulin resistance in offspring. In the general population, high folate exacerbates the increase of methylmalonic acid, a marker of vitamin B12 deficiency. However, the influence of vitamin B12 and folate and their related markers on insulin resistance and metabolic syndrome remains unknown in severe obesity. To evaluate the influence of vitamin B12 and folate on HOMA-IR and components of metabolic syndrome in severe obesity. 278 consecutive obese patients were assessed prospectively for HOMA-IR, red blood cell (RBC) folates, homocysteine and methylmalonic acid. We compared the associations with the components of metabolic syndrome during the preoperative multidisciplinary evaluation (period-1) and before bariatric surgery (period-2). The HOMA-IR was higher in patients with highest tertile of RBC and either lowest tertile of plasma B12 or highest tertile of MMA (p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2017.07.008