Heck arylation of allylic alcohols in molten salts

The Heck coupling of ArX (X=I, Br) with allylic alcohols, carried out at 80–120 °C in molten n-Bu 4NBr using NaHCO 3 as base and PdCl 2 as catalyst without extra ligands, leads to the corresponding β-arylated carbonyl compounds. After extraction of the organic materials with diethyl ether, the ionic...

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Bibliographic Details
Published in:Journal of organometallic chemistry 2001-09, Vol.634 (2), p.153-156
Main Authors: Bouquillon, Sandrine, Ganchegui, Benjamin, Estrine, Boris, Hénin, Françoise, Muzart, Jacques
Format: Article
Language:English
Subjects:
Allylic alcohols
Chemical Sciences
Heck reactions
Molten ammonium salts
Recycling
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Summary:The Heck coupling of ArX (X=I, Br) with allylic alcohols, carried out at 80–120 °C in molten n-Bu 4NBr using NaHCO 3 as base and PdCl 2 as catalyst without extra ligands, leads to the corresponding β-arylated carbonyl compounds. After extraction of the organic materials with diethyl ether, the ionic layer can be reused directly. The synthesis of β-arylated carbonyl compounds including nabumethone has been carried out in molten n-Bu 4NBr using NaHCO 3 as base and PdCl 2 as catalyst without extra ligands.
ISSN:0022-328X
1872-8561
0022-328X
DOI:10.1016/S0022-328X(01)01149-4