Angiogenic factors sFlt-1 and PlGF in preeclampsia: Prediction of risk and prognosis in a high-risk obstetric population

• Published in: Journal of gynecology obstetrics and human reproduction 2018-01, Vol.47 (1), p.17-21
• Main Authors: Tardif, C., Dumontet, E., Caillon, H., Misbert, E., Dochez, V., Masson, D., Winer, N.
• Format: Article
• Language: English
• Subjects: Angiogenic factors; Life Sciences; Prediction in high-risk pregnancies; Preeclampsia; Ratio sFlt-1/PlGF
• ISSN: 2468-7847; 2468-8495; 2468-7847
• DOI: 10.1016/j.jogoh.2017.10.007

Despite its simple definition, preeclampsia can have variable and atypical clinical presentations, an unpredictable course, and potential adverse maternal and fetal outcomes. No single test currently predicts risk or prognosis adequately. Scientific advances suggest that an angiogenic imbalance is involved in its pathophysiology. The objective of this study was to investigate the use of sFlt-1, PlGF, and their ratio in predicting preeclampsia. In a single-center prospective observational study, we measured the angiogenic markers sFlt-1 and PlGF and calculated the sFlt-1/PlGF ratio in patients at risk of preeclampsia at 20 to 37 weeks of gestation. The main outcomes were the occurrence of preeclampsia and the interval before its onset. Of the 67 at risk patients included, 8 (12%) developed preeclampsia. For a sFlt-1/PlGF ratio ≥85, the specificity was 93%. The ratio was significantly higher (ratio=104±30) in women with an onset time less than 5 weeks than in those with later preeclampsia (ratio=10±2), P