Increased Sensitivity of Prediabetic Nonobese Diabetic Mouse to the Behavioral Effects of IL-1

The nonobese diabetic (NOD) mouse is a model of spontaneous insulin-dependent diabetes mellitus (IDDM) or type I diabetes. In humans, and in animal models of IDDM, the progression of the disease is modulated by various environmental factors, particularly infectious agents. Interleukin-1 (IL-1) plays...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 1999-12, Vol.13 (4), p.303-314
Main Authors: Bluthé, Rose-Marie, Jafarian-Tehrani, Mehrnaz, Michaud, Bruno, Haour, France, Dantzer, Robert, Homo-Delarche, Francoise
Format: Article
Language:English
Subjects:
Animals
behavior
Behavior, Animal - drug effects
Behavior, Animal - physiology
Body Weight - drug effects
Brain Chemistry - drug effects
brain IL-1 receptors
Endotoxins - pharmacology
Escherichia coli
Exploratory Behavior - drug effects
infection
interleukin 1 receptors
interleukin-1 (IL-1)
Interleukin-1 - pharmacology
Key words: NOD mouse
Life Sciences
Lipopolysaccharides - pharmacology
Male
Mice
Mice, Inbred ICR
Mice, Inbred NOD
Motor Activity - drug effects
Prediabetic State - genetics
Prediabetic State - psychology
Receptors, Interleukin-1 - metabolism
Recombinant Proteins - pharmacology
Social Behavior
stress
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Summary:The nonobese diabetic (NOD) mouse is a model of spontaneous insulin-dependent diabetes mellitus (IDDM) or type I diabetes. In humans, and in animal models of IDDM, the progression of the disease is modulated by various environmental factors, particularly infectious agents. Interleukin-1 (IL-1) plays a pivotal role in the development of IDDM, and modulation of its synthesis may be a mechanism by which environmental modulation of disease progression occurs. Since various alterations at the level of the gene, number, and sensitivity of IL-1 receptors have been described in different animal models of autoimmune disease, we investigated, in the prediabetic NOD mouse, the presence of IL-1 receptors and their functional behavioral characteristics. Here we present evidence that prediabetic NOD mice exhibit a normal distribution and density of functional brain IL-1 receptors, but are more sensitive to the behavioral effects of IL-1 than the control ICR strain.
ISSN:0889-1591
1090-2139
DOI:10.1006/brbi.1998.0542