Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort

The aims of the present study were to describe treatment patterns and survival outcomes in patients with central nervous system metastases (CNSM) selected among metastatic breast cancer (MBC) patients included in a retrospective study from the Epidemiological Strategy and Medical Economics (ESME) MB...

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Published in:European journal of cancer (1990) 2020-01, Vol.125, p.22-30
Main Authors: Pasquier, David, Darlix, Amélie, Louvel, Guillaume, Fraisse, Julien, Jacot, William, Brain, Etienne, Petit, Adeline, Mouret-Reynier, Marie Ange, Goncalves, Anthony, Dalenc, Florence, Deluche, Elise, Fresnel, Jean Sébastien, Augereau, Paule, Ferrero, Jean Marc, Geffrelot, Julien, Fumet, Jean-David, Lecouillard, Isabelle, Cottu, Paul, Petit, Thierry, Uwer, Lionel, Jouannaud, Christelle, Leheurteur, Marianne, Dieras, Véronique, Robain, Mathieu, Mouttet-Audouard, Raphaelle, Bachelot, Thomas, Courtinard, Coralie
Format: Article
Language:English
Subjects:
Brain metastases
Breast cancer
Cancer
Central nervous system
Diagnosis
Epidemiology
ErbB-2 protein
Life Sciences
Metastases
Metastasis
Metastatic breast cancer
Multivariate analysis
Nervous system
Neurological progression-free survival
Patients
Radiation
Radiation therapy
Statistical models
Survival
Tumors
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Summary:The aims of the present study were to describe treatment patterns and survival outcomes in patients with central nervous system metastases (CNSM) selected among metastatic breast cancer (MBC) patients included in a retrospective study from the Epidemiological Strategy and Medical Economics (ESME) MBC cohort. Neurological progression-free survival (NPFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Significant contributors to NPFS were determined using a multivariate Cox proportional hazards model. After a median follow-up of 42.8 months, of 16 701 patients included in the ESME MBC database, CNSM were diagnosed in 24.6% of patients. The most frequent treatments after diagnosis of CNSM were whole-brain radiotherapy (WBRT) (45.2%) and systemic treatment (59.3%). Median OS and NPFS were 7.9 months (95% CI: 7.2–8.4) and 5.5 months (95% CI: 5.2–5.8), respectively. In multivariate analysis, age >70 years (vs
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2019.11.001