One‐year clinical outcomes in patients with chronic kidney disease treated with COMBO stents: From the COMBO collaboration

Background Chronic kidney disease (CKD) patients undergoing percutaneous coronary intervention (PCI) experience greater ischemic events including clinically driven target lesion revascularization (CD‐TLR). Whether the COMBO biodegradable‐polymer sirolimus‐eluting stent promotes better outcomes in th...

Full description

Saved in:
Bibliographic Details
Published in:Catheterization and cardiovascular interventions 2021-11, Vol.98 (6), p.1095-1101
Main Authors: Chandrasekhar, Jaya, Kalkman, Deborah N., Sartori, Samantha, Baber, Usman, Blum, Moritz, Aquino, Melissa B., Woudstra, Pier, Beijk, Marcel A., Tijssen, Jan G., Koch, Karel T., Dangas, George D., Colombo, Antonio, Winter, Robbert J., Mehran, Roxana
Format: Article
Language:English
Subjects:
Biodegradability
chronic kidney disease
Clopidogrel
Collaboration
COMBO PCI
Death
dual therapy stent
endothelial progenitor cell capture
Heart
Implants
Ischemia
Kidney diseases
Life Sciences
Myocardial infarction
Patients
Polymers
Progenitor cells
Rapamycin
Stem cells
Stents
Thrombosis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Chronic kidney disease (CKD) patients undergoing percutaneous coronary intervention (PCI) experience greater ischemic events including clinically driven target lesion revascularization (CD‐TLR). Whether the COMBO biodegradable‐polymer sirolimus‐eluting stent promotes better outcomes in these patients by virtue of endothelial progenitor cell capture technology is unknown. Objective We examined one‐year outcomes by CKD status from the COMBO collaboration. Methods The COMBO collaboration was a patient‐level pooled dataset from the REMEDEE and MASCOT registries (3,614 patients) of all‐comers undergoing attempted COMBO stent PCI. The primary endpoint was one‐year target lesion failure (TLF), composite of cardiac death, target‐vessel myocardial infarction (TV‐MI) or CD‐TLR. Secondary endpoints included stent thrombosis (ST). Results The study included 6.4% (n = 231) CKD and 93.6% (n = 3,361) non‐CKD patients. CKD patients were older and included more women with greater prevalence of several comorbidities but similar rate of acute coronary syndrome (50.6% vs. 54.5%, p = .26). CKD patients underwent radial PCI less often (56.1% vs. 70.3%, p 
ISSN:1522-1946
1522-726X
DOI:10.1002/ccd.29270