Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction

Inhibition of the interleukin (IL)-1β innate immunity pathway is associated with anti-inflammatory effects and a reduced risk of recurrent cardiovascular events in stable patients with previous myocardial infarction (MI) and elevated high-sensitivity C-reactive protein (hs-CRP). This study assessed...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2020-10, Vol.76 (15), p.1763-1773
Main Authors: Silvain, Johanne, Kerneis, Mathieu, Zeitouni, Michel, Lattuca, Benoit, Galier, Sophie, Brugier, Delphine, Mertens, Emilie, Procopi, Niki, Suc, Gaspard, Salloum, Tomy, Frisdal, Eric, Le Goff, Wilfried, Collet, Jean-Philippe, Vicaut, Eric, Lesnik, Philippe, Montalescot, Gilles, Guerin, Maryse
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
C-reactive protein
Coronary Angiography
Female
Follow-Up Studies
France - epidemiology
Humans
inflammation
Interleukin-18 - blood
interleukin-1β
Life Sciences
Male
Middle Aged
mortality
Mortality, Premature - trends
myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - mortality
Prospective Studies
Risk Assessment - methods
Risk Factors
Survival Rate - trends
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Summary:Inhibition of the interleukin (IL)-1β innate immunity pathway is associated with anti-inflammatory effects and a reduced risk of recurrent cardiovascular events in stable patients with previous myocardial infarction (MI) and elevated high-sensitivity C-reactive protein (hs-CRP). This study assessed the association between IL-1β level with all-cause mortality in patients with acute ST-segment elevation MI who underwent primary percutaneous coronary intervention and the interplay between IL-1β and hs-CRP concentrations on the risk of premature death. IL-1β concentration was measured in 1,398 patients with ST-segment elevation MI who enrolled in a prospective cohort. Crude and hazard ratios for all-cause and cardiovascular mortality were analyzed at 90 days and 1 year using multivariate Cox proportional regression analysis. Major adverse cardiovascular events (MACEs) were analyzed. IL-1β concentration measured at admission was associated with all-cause mortality at 90 days (adjusted hazard ratio [adjHR]: 1.47 per 1 SD increase; 95% confidence interval [CI]: 1.16 to 1.87; p 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2020.08.026