Enhanced Discriminative Abilities of Auditory Cortex Neurons for Pup Calls Despite Reduced Evoked Responses in C57BL/6 Mother Mice

• Published in: Neuroscience 2021-01, Vol.453, p.1-16
• Main Authors: Royer, Juliette, Huetz, Chloé, Occelli, Florian, Cancela, José-Manuel, Edeline, Jean-Marc
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Animals; Auditory Brainstem Response (ABR); Auditory Cortex; Auditory Perception; communication sounds; cortical discrimination; Evoked Potentials, Auditory; Female; Guinea Pigs; Humans; Life Sciences; Mice; Mice, Inbred C57BL; motherhood; Mothers; mutual information; Neurons; Neurons and Cognition; noise correlations; Vocalization, Animal
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2020.11.031

•ABR thresholds were similar in mother vs. in virgin mice but latencies were shorter.•Evoked cortical responses were decreased in mothers compared to virgins.•Cortical response latencies were shorter in mothers than in virgins.•The MI per spike was higher in mothers than in virgins only for pup calls.•The noise correlations were lower in mothers than in virgins for all stimuli. A fundamental task for the auditory system is to process communication sounds according to their behavioral significance. In many mammalian species, pup calls became more significant for mothers than other conspecific and heterospecific communication sounds. To study the cortical consequences of motherhood on the processing of communication sounds, we recorded neuronal responses in the primary auditory cortex of virgin and mother C57BL/6 mice which had similar ABR thresholds. In mothers, the evoked firing rate in response to pure tones was decreased and the frequency receptive fields were narrower. The responses to pup and adult calls were also reduced but the amount of mutual information (MI) per spike about the pup call’s identity was increased in mother mice. The response latency to pup and adult calls was significantly shorter in mothers. Despite similarly decreased responses to guinea pig whistles, the response latency, and the MI per spike did not differ between virgins and mothers for these heterospecific vocalizations. Noise correlations between cortical recordings were decreased in mothers, suggesting that the firing rate of distant neurons was more independent from each other. Together, these results indicate that in the most commonly used mouse strain for behavioral studies, the discrimination of pup calls by auditory cortex neurons is more efficient during motherhood.