Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer

Decreased health-related quality of life (HRQoL) is common in patients with cancer. We investigated the effects of dietary intervention and baseline nutritional status on worsening of HRQoL in older patients during chemotherapy. In this randomized control trial assessing the effect on mortality of d...

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Bibliographic Details
Published in:Supportive care in cancer 2021-02, Vol.29 (2), p.687-696
Main Authors: Regueme, Sophie C., Echeverria, Iñaki, Monéger, Nicolas, Durrieu, Jessica, Becerro-Hallard, Maïté, Duc, Sophie, Lafargue, Aurelie, Mertens, Cécile, Laksir, Hamid, Ceccaldi, Joël, Lavau-Denes, Sandrine, Dantoine, Thierry, Irazusta, Jon, Bourdel-Marchasson, Isabelle
Format: Article
Language:English
Subjects:
Activities of daily living
Aged
Aged patients
Analysis
Cancer
Cancer patients
Chemotherapy
Diet Therapy - methods
Energy Intake - physiology
Fatigue
Female
Humans
Life Sciences
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Mortality
Neoplasms - complications
Neoplasms - drug therapy
Nursing
Nursing Research
Nutrition
Nutrition Therapy - methods
Older people
Oncology
Original Article
Pain Medicine
Product/Service Evaluations
Proteins
Quality of life
Quality of Life - psychology
Rehabilitation Medicine
Weight loss
Weight Loss - physiology
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Summary:Decreased health-related quality of life (HRQoL) is common in patients with cancer. We investigated the effects of dietary intervention and baseline nutritional status on worsening of HRQoL in older patients during chemotherapy. In this randomized control trial assessing the effect on mortality of dietary advice to increase dietary intake during chemotherapy, this post hoc analysis included 155 patients with cancer at risk of malnutrition. The effects of dietary intervention, baseline Mini Nutritional Assessment item scores, weight loss, and protein and energy intake before treatment on the worsening of HRQoL (physical functioning, fatigue) and secondary outcomes (Timed Up and Go test, one-leg stance time, depressive symptoms, basic (ADL), or instrumental (IADL) activities of daily living) were analyzed by multinomial regressions. Dietary intervention increased total energy and protein intake but had no effect on any examined outcomes. Worsening of fatigue and ADL was predicted by very low protein intake (
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-020-05528-4