Analgesic effects of dyspnoea: “Air hunger” does not inhibit the spinal nociception reflex in humans

Highlights • Dyspnoea has antinociceptive effects in humans. • This is true for both air hunger and the sensation of excessive respiratory work/effort. • Spinal inhibition (diffuse nociceptive inhibitory controls) is one of the mechanisms of dyspnoea-pain counter-irritation. • Yet spinal inhibition...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2014-01, Vol.190, p.81-85
Main Authors: Morélot-Panzini, Capucine, Mayaux, Julien, Hug, François, Willer, Jean-Claude, Similowski, Thomas
Format: Article
Language:English
Subjects:
Adult
Adult Analgesia Carbon Dioxide / administration & dosage Dyspnea / chemically induced Dyspnea / physiopathology Electromyography Female Humans Hypercapnia / physiopathology Male Neural Inhibition Nociception / drug effects Nociception / physiology Reflex / drug effects Spinal Cord / drug effects Spinal Cord / physiology
Air hunger
Analgesia
C-fibres
Carbon Dioxide - administration & dosage
Dyspnea - chemically induced
Dyspnea - physiopathology
Dyspnoea
Electromyography
Female
Humans
Hypercapnia - physiopathology
Life Sciences
Male
Medical Education
Neural Inhibition
Nociception - drug effects
Nociception - physiology
Nociceptive flexor reflex
Pain
Pulmonary/Respiratory
Reflex - drug effects
Spinal Cord - drug effects
Spinal Cord - physiology
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Summary:Highlights • Dyspnoea has antinociceptive effects in humans. • This is true for both air hunger and the sensation of excessive respiratory work/effort. • Spinal inhibition (diffuse nociceptive inhibitory controls) is one of the mechanisms of dyspnoea-pain counter-irritation. • Yet spinal inhibition does not occur in response to experimental air hunger in normal humans (this study). • The analgesic effects of air hunger therefore probably proceed from central phenomena.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2013.09.012